Tmt1b thiol methyltransferase 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmt1bprovided by MGI
Official Full Name: thiol methyltransferase 1Bprovided by MGI
Primary source: MGI:MGI:1918914
See related: Ensembl:ENSMUSG00000025347 AllianceGenome:MGI:1918914
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mettl7b; 0610006F02Rik
Summary: Predicted to enable thiol S-methyltransferase activity. Predicted to be involved in methylation. Predicted to be located in cytosol; endoplasmic reticulum membrane; and lipid droplet. Is expressed in several structures, including alimentary system; brain; genitourinary system; liver; and spleen. Orthologous to human TMT1B (thiol methyltransferase 1B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in liver adult (RPKM 329.6), kidney adult (RPKM 92.7) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 77.2 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128794146..128796857, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128958277..128960988, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization.
Title: Methyltransferase like 7B is upregulated in sepsis and modulates lipopolysaccharide-induced inflammatory response and macrophage polarization.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itga7 (e-PCR), detects polymorphism
- UniSTS:143623

AI266817 (e-PCR)
- UniSTS:160041

D10Utsw1 (e-PCR), detects polymorphism
- UniSTS:534570

L23423 (e-PCR)
- UniSTS:124879

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables S-adenosylmethionine-dependent methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables S-adenosylmethionine-dependent methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables thiol S-methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables thiol S-methyltransferase activity	ISO Inferred from Sequence Orthology more info
enables thiol S-methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thiol S-methyltransferase TMT1B

Names: methyltransferase like 7B; methyltransferase-like protein 7B; thiol S-methyltransferase METTL7B

NP_082129.2

EC 2.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027853.2 → NP_082129.2 thiol S-methyltransferase TMT1B precursor

See identical proteins and their annotated locations for NP_082129.2

Status: VALIDATED

Source sequence(s)

AK002239

Consensus CDS

CCDS24301.1

UniProtKB/Swiss-Prot

Q78ID2, Q9DD20

Related

ENSMUSP00000026398.4, ENSMUST00000026398.5

Conserved Domains (2) summary

COG0500
Location:33 → 192

SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]

pfam08241
Location:75 → 172

Methyltransf_11; Methyltransferase domain