U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Npas2 neuronal PAS domain protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 18143, updated on 9-Dec-2024

    Summary

    Official Symbol
    Npas2provided by MGI
    Official Full Name
    neuronal PAS domain protein 2provided by MGI
    Primary source
    MGI:MGI:109232
    See related
    Ensembl:ENSMUSG00000026077 AllianceGenome:MGI:109232
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MOP4; bHLHe9
    Summary
    The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. The encoded protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Dec 2014]
    Expression
    Broad expression in small intestine adult (RPKM 16.1), colon adult (RPKM 13.4) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Npas2 in Genome Data Viewer
    Location:
    1 B; 1 17.98 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39233013..39402321)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39193702..39363240)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35222 Neighboring gene STARR-seq mESC enhancer starr_00703 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39148051-39148289 Neighboring gene STARR-seq mESC enhancer starr_00706 Neighboring gene STARR-seq mESC enhancer starr_00707 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39249153-39249481 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39249871-39249980 Neighboring gene microRNA 6349 Neighboring gene predicted gene 20428 Neighboring gene microrchidia 2A pseudogene Neighboring gene STARR-seq mESC enhancer starr_00710 Neighboring gene ribosomal protein L17 pseudogene Neighboring gene predicted gene, 53549 Neighboring gene TBC1 domain family, member 8 Neighboring gene ribosomal protein L31 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39535681-39535790 Neighboring gene STARR-seq mESC enhancer starr_00719 Neighboring gene predicted gene, 24826

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129355

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
     
    enables Hsp90 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in DNA damage response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in circadian regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in circadian regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in circadian rhythm IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    acts_upstream_of_or_within circadian sleep/wake cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within locomotor rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA repair ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of behavioral fear response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of circadian rhythm IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to redox state IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to redox state ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in response to redox state ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to xenobiotic stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CLOCK-BMAL transcription complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    neuronal PAS domain-containing protein 2
    Names
    neuronal PAS2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008719.2NP_032745.2  neuronal PAS domain-containing protein 2

      See identical proteins and their annotated locations for NP_032745.2

      Status: VALIDATED

      Source sequence(s)
      BB524729, BC109166, BG070037, U77969
      Consensus CDS
      CCDS48244.1
      UniProtKB/Swiss-Prot
      P97460
      UniProtKB/TrEMBL
      G3X9B7
      Related
      ENSMUSP00000054719.8, ENSMUST00000056815.9
      Conserved Domains (4) summary
      TIGR02813
      Location:440740
      omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA
      pfam00989
      Location:84195
      PAS; PAS fold
      pfam14598
      Location:249352
      PAS_11; PAS domain
      cd19737
      Location:177
      bHLH-PAS_NPAS2_PASD4; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 2 (NPAS2) and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      39233013..39402321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011238452.4XP_011236754.1  neuronal PAS domain-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011236754.1

      UniProtKB/Swiss-Prot
      P97460
      UniProtKB/TrEMBL
      G3X9B7
      Conserved Domains (4) summary
      TIGR02813
      Location:440740
      omega_3_PfaA; polyketide-type polyunsaturated fatty acid synthase PfaA
      pfam00989
      Location:84195
      PAS; PAS fold
      pfam14598
      Location:249352
      PAS_11; PAS domain
      cd19737
      Location:177
      bHLH-PAS_NPAS2_PASD4; basic helix-loop-helix-Per-ARNT-Sim (bHLH-PAS) domain found in neuronal PAS domain-containing protein 2 (NPAS2) and similar proteins