Nme5 NME/NM23 family member 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nme5provided by MGI
Official Full Name: NME/NM23 family member 5provided by MGI
Primary source: MGI:MGI:1922783
See related: Ensembl:ENSMUSG00000035984 AllianceGenome:MGI:1922783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nm23-M5; 1700019D05Rik
Summary: Predicted to enable 3'-5' exonuclease activity. Involved in spermatid development. Acts upstream of or within several processes, including epithelial cilium movement involved in extracellular fluid movement; negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway; and ventricular system development. Located in sperm flagellum. Part of radial spoke. Is expressed in lung epithelium; nasal cavity respiratory epithelium; and nasopharynx epithelium. Used to study hydrocephalus. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia. Orthologous to human NME5 (NME/NM23 family member 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis adult (RPKM 41.1), lung adult (RPKM 2.7) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 B1; 18 18.69 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (34695687..34712168, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (34562634..34579152, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Situs inversus, hydrocephalus, suppurative rhinosinusitis,and sperm flagellar defects in Nme5 null mice are indicative of defective ciliogenesis
Title: Congenital hydrocephalus in genetically engineered mice.
results reveal that expression of Nm23-M5 plays a critical role in spermiogenesis by increasing the cellular levels of GPX-5 to eliminate reactive oxygen species
Title: Nm23-M5 mediates round and elongated spermatid survival by regulating GPX-5 levels.
Nme5 is most abundantly expressed in tissues rich in highly ciliated cells, such as olfactory sensory neurons, and is predicted to be important to cilia.
Title: Tissue expression patterns identify mouse cilia genes.
nm23-M5 gene plays an important role in late spermiogenesis by elevating the ability of late-stage spermatids to eliminate reactive oxygen species
Title: Cloning, sequencing, and characterization of the murine nm23-M5 gene during mouse spermatogenesis and spermiogenesis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5' exonuclease activity	ISO Inferred from Sequence Orthology more info
enables 3'-5' exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleoside diphosphate kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in CTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GTP biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in UTP biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial cilium movement involved in extracellular fluid movement	IC Inferred by Curator more info	PubMed
acts_upstream_of_or_within epithelial cilium movement involved in extracellular fluid movement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IC Inferred by Curator more info	PubMed
involved_in mating	IC Inferred by Curator more info	PubMed
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in response to reactive oxygen species	NAS Non-traceable Author Statement more info	PubMed
involved_in spermatid development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatid development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ventricular system development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in 9+2 motile cilium	IC Inferred by Curator more info	PubMed
located_in 9+2 motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
part_of radial spoke	IDA Inferred from Direct Assay more info	PubMed
located_in sperm flagellum	IC Inferred by Curator more info	PubMed
located_in sperm flagellum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: nucleoside diphosphate kinase homolog 5

Names: 3'-5' exonuclease NME5; NDK-H 5; NDP kinase homolog 5; expressed in non-metastatic cells 5; non-metastatic cells 5, protein expressed in (nucleoside-diphosphate kinase); rsph23

NP_542368.2

EC 2.7.4.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080637.4 → NP_542368.2 nucleoside diphosphate kinase homolog 5

See identical proteins and their annotated locations for NP_542368.2

Status: VALIDATED

Source sequence(s)

AC074335, AK131722, BC049625

Consensus CDS

CCDS29130.1

UniProtKB/Swiss-Prot

Q810R1, Q99MH5

UniProtKB/TrEMBL

Q3V2L8

Related

ENSMUSP00000078269.6, ENSMUST00000079287.12

Conserved Domains (3) summary

smart00562
Location:13 → 148

NDK; Enzymes that catalyze nonsubstrate specific conversions of nucleoside diphosphates to nucleoside triphosphates

cd04418
Location:13 → 144

NDPk5; Nucleoside diphosphate kinase homolog 5 (NDP kinase homolog 5, NDPk5, NM23-H5; Inhibitor of p53-induced apoptosis-beta, IPIA-beta): In human, mRNA for NDPk5 is almost exclusively found in testis, especially in the flagella of spermatids and spermatozoa, ...

pfam05186
Location:156 → 197

Dpy-30; Dpy-30 motif