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    Pear1 platelet endothelial aggregation receptor 1 [ Mus musculus (house mouse) ]

    Gene ID: 73182, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pear1provided by MGI
    Official Full Name
    platelet endothelial aggregation receptor 1provided by MGI
    Primary source
    MGI:MGI:1920432
    See related
    Ensembl:ENSMUSG00000028073 AllianceGenome:MGI:1920432
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Jedi-1; Megf12; 3110045G13Rik
    Summary
    Enables signaling receptor activity. Involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction; platelet aggregation; and positive regulation of platelet activation. Acts upstream of or within recognition of apoptotic cell. Located in phagocytic cup. Is active in plasma membrane. Is expressed in brain; dorsal root ganglion; embryo; heart; and spinal cord. Orthologous to human PEAR1 (platelet endothelial aggregation receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in ovary adult (RPKM 34.7), mammary gland adult (RPKM 30.0) and 24 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Pear1 in Genome Data Viewer
    Location:
    3 F1; 3 38.5 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (87656404..87676262, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (87749097..87769110, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 11 Neighboring gene predicted gene 6570 Neighboring gene leucine rich repeat containing 71 Neighboring gene neurotrophic tyrosine kinase, receptor, type 1 Neighboring gene insulin receptor-related receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2)  1 citation

    General protein information

    Preferred Names
    platelet endothelial aggregation receptor 1
    Names
    Jedi
    jagged and Delta protein
    mPEAR1
    multiple EGF-like domains protein 12
    multiple epidermal growth factor-like domains protein 12
    protein Jedi

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001032413.1NP_001027585.1  platelet endothelial aggregation receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001027585.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC122439, AK053551, BB848869
      Consensus CDS
      CCDS38474.1
      UniProtKB/Swiss-Prot
      Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
      Related
      ENSMUSP00000133323.2, ENSMUST00000174759.8
      Conserved Domains (2) summary
      pfam07546
      Location:2593
      EMI; EMI domain
      cl21504
      Location:535580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    2. NM_001032414.1NP_001027586.1  platelet endothelial aggregation receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_001027586.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC122439, AF440279, AK014179, BB848869
      Consensus CDS
      CCDS38474.1
      UniProtKB/Swiss-Prot
      Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
      Related
      ENSMUSP00000078090.6, ENSMUST00000079083.12
      Conserved Domains (2) summary
      pfam07546
      Location:2593
      EMI; EMI domain
      cl21504
      Location:535580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    3. NM_001289600.1NP_001276529.1  platelet endothelial aggregation receptor 1 isoform b

      See identical proteins and their annotated locations for NP_001276529.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate splice junction at the 5' end of an exon, which causes translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC161454, AK141082, BB848869
      UniProtKB/Swiss-Prot
      Q8VIK5
      Conserved Domains (1) summary
      cl21504
      Location:456501
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    4. NM_001289601.1NP_001276530.1  platelet endothelial aggregation receptor 1 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) has several internal differences, which causes translation initiation at an alternate start codon, compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC161454, AK141082, AK161049, BB848869
      UniProtKB/Swiss-Prot
      Q8VIK5
      Conserved Domains (2) summary
      NF033759
      Location:171369
      exchanger_TraA; outer membrane exchange protein TraA
      cl21504
      Location:283328
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    5. NM_028460.2NP_082736.1  platelet endothelial aggregation receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_082736.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC122439, AF440279, BB848869
      Consensus CDS
      CCDS38474.1
      UniProtKB/Swiss-Prot
      Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
      Related
      ENSMUSP00000133474.2, ENSMUST00000172621.8
      Conserved Domains (2) summary
      pfam07546
      Location:2593
      EMI; EMI domain
      cl21504
      Location:535580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    6. NM_152799.2NP_690012.2  platelet endothelial aggregation receptor 1 isoform a precursor

      See identical proteins and their annotated locations for NP_690012.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC122439, AF440279, BB848869, BY236825
      Consensus CDS
      CCDS38474.1
      UniProtKB/Swiss-Prot
      Q3URX7, Q6KAQ6, Q8CGA7, Q8VHF4, Q8VHL7, Q8VIK5
      Conserved Domains (2) summary
      pfam07546
      Location:2593
      EMI; EMI domain
      cl21504
      Location:535580
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      87656404..87676262 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163352.1XP_036019245.1  platelet endothelial aggregation receptor 1 isoform X1

      Conserved Domains (2) summary
      NF033759
      Location:171369
      exchanger_TraA; outer membrane exchange protein TraA
      cl21504
      Location:283328
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...