U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Sh3tc1 SH3 domain and tetratricopeptide repeats 1 [ Mus musculus (house mouse) ]

    Gene ID: 231147, updated on 9-Dec-2024

    Summary

    Official Symbol
    Sh3tc1provided by MGI
    Official Full Name
    SH3 domain and tetratricopeptide repeats 1provided by MGI
    Primary source
    MGI:MGI:2678949
    See related
    Ensembl:ENSMUSG00000036553 AllianceGenome:MGI:2678949
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4631428G15
    Summary
    Is expressed in embryo mesenchyme and meninges. Orthologous to human SH3TC1 (SH3 domain and tetratricopeptide repeats 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in lung adult (RPKM 14.6), kidney adult (RPKM 12.2) and 18 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Sh3tc1 in Genome Data Viewer
    Location:
    5 B3; 5 18.6 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (35854524..35897331, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (35697180..35739987, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931431C16 gene Neighboring gene STARR-positive B cell enhancer ABC_E3570 Neighboring gene STARR-positive B cell enhancer ABC_E11725 Neighboring gene acyl-Coenzyme A oxidase 3, pristanoyl Neighboring gene HtrA serine peptidase 3 Neighboring gene STARR-seq mESC enhancer starr_12860 Neighboring gene predicted gene, 31888 Neighboring gene STARR-positive B cell enhancer ABC_E8820 Neighboring gene actin-binding LIM protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E8050 Neighboring gene actin filament associated protein 1 Neighboring gene H2A histone family, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

    Markers

    Clone Names

    • MGC67153

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
     

    General protein information

    Preferred Names
    SH3 domain and tetratricopeptide repeat-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359895.1NP_001346824.1  SH3 domain and tetratricopeptide repeat-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AC122871, AK167283
      Consensus CDS
      CCDS19234.2
      UniProtKB/TrEMBL
      G3X9F6, Q3TXV8, Q3UDI4
      Related
      ENSMUSP00000144175.2, ENSMUST00000201511.2
      Conserved Domains (3) summary
      cd11885
      Location:313367
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:11631190
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:11661231
      TPR_12; Tetratricopeptide repeat
    2. NM_194344.2NP_919325.2  SH3 domain and tetratricopeptide repeat-containing protein 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK150064, AK159089, BY201660, BY513538
      Consensus CDS
      CCDS19234.2
      UniProtKB/TrEMBL
      G3X9F6, Q3TXV8, Q3UDI4
      Related
      ENSMUSP00000070610.8, ENSMUST00000070203.14
      Conserved Domains (3) summary
      cd11885
      Location:313367
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:11631190
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:11661231
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      35854524..35897331 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503904.4XP_006503967.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      G3X9F6, Q3TXV8, Q3UDI4
      Related
      ENSMUSP00000115376.2, ENSMUST00000127825.8
      Conserved Domains (3) summary
      cd11885
      Location:313367
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:11631190
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:11661231
      TPR_12; Tetratricopeptide repeat
    2. XM_036165020.1XP_036020913.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      Q3TXV8, Q3UDI4
      Conserved Domains (3) summary
      cd11885
      Location:288342
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:11381165
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:11411206
      TPR_12; Tetratricopeptide repeat
    3. XM_036165021.1XP_036020914.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      Q3TXV8, Q3UDI4
      Conserved Domains (3) summary
      cd11885
      Location:119173
      SH3_SH3TC; Src Homology 3 domain of SH3 domain and tetratricopeptide repeat-containing (SH3TC) proteins and similar domains
      sd00006
      Location:969996
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:9721037
      TPR_12; Tetratricopeptide repeat
    4. XM_006503905.3XP_006503968.1  SH3 domain and tetratricopeptide repeat-containing protein 1 isoform X4

      UniProtKB/TrEMBL
      Q6KAR4
      Conserved Domains (2) summary
      sd00006
      Location:813840
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:816881
      TPR_12; Tetratricopeptide repeat