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    Ubr2 ubiquitin protein ligase E3 component n-recognin 2 [ Mus musculus (house mouse) ]

    Gene ID: 224826, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ubr2provided by MGI
    Official Full Name
    ubiquitin protein ligase E3 component n-recognin 2provided by MGI
    Primary source
    MGI:MGI:1861099
    See related
    Ensembl:ENSMUSG00000023977 AllianceGenome:MGI:1861099
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA0349; 9930021A08Rik; E130209G04Rik
    Summary
    Enables histone H2A ubiquitin ligase activity. Involved in several processes, including heterochromatin formation; meiotic nuclear division; and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Acts upstream of or within male meiosis I and ubiquitin-dependent protein catabolic process. Located in chromatin. Part of ubiquitin ligase complex. Is expressed in several structures, including alimentary system; endocrine gland; eye; genitourinary system; and trachea. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.1), thymus adult (RPKM 12.0) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ubr2 in Genome Data Viewer
    Location:
    17 C; 17 22.91 cM
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (47239217..47321812, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46928291..47010886, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E170 Neighboring gene STARR-seq mESC enhancer starr_42692 Neighboring gene tubulin-specific chaperone C Neighboring gene peripherin 2 Neighboring gene STARR-positive B cell enhancer ABC_E3205 Neighboring gene STARR-positive B cell enhancer ABC_E4216 Neighboring gene non-histone chromosomal protein HMG-17 pseudogene Neighboring gene ribosomal protein L29 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0349, MGC36320

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables L-leucine binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables L-leucine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables histone H2A ubiquitin ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin protein ligase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to L-leucine ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in heterochromatin formation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within male meiosis I IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of TOR signaling ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of TOR signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein K63-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein K63-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in reciprocal meiotic recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in transposable element silencing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in ubiquitin-dependent protein catabolic process via the N-end rule pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase UBR2
    Names
    N-recognin-2
    RING-type E3 ubiquitin transferase UBR2
    ubiquitin ligase E3 alpha-II
    ubiquitin-protein ligase E3-alpha-2
    ubiquitin-protein ligase E3-alpha-II
    NP_001170845.1
    NP_666190.2
    XP_006524208.1
    XP_030105595.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001177374.2NP_001170845.1  E3 ubiquitin-protein ligase UBR2 isoform 2

      See identical proteins and their annotated locations for NP_001170845.1

      Status: VALIDATED

      Source sequence(s)
      AC165289, AC170807
      Consensus CDS
      CCDS50127.1
      UniProtKB/TrEMBL
      Q3UHE0, Q3UPU3
      Related
      ENSMUSP00000108961.3, ENSMUST00000113335.4
      Conserved Domains (2) summary
      pfam02207
      Location:99166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS
    2. NM_146078.4NP_666190.2  E3 ubiquitin-protein ligase UBR2 isoform 1

      See identical proteins and their annotated locations for NP_666190.2

      Status: VALIDATED

      Source sequence(s)
      AC165289, AC170807
      Consensus CDS
      CCDS28845.1
      UniProtKB/Swiss-Prot
      Q6DIB9, Q6WKZ8, Q80U31, Q8BUL9, Q8CGW0, Q8K2I6, Q8R0V7, Q8R130
      UniProtKB/TrEMBL
      Q3UHE0
      Related
      ENSMUSP00000108963.3, ENSMUST00000113337.10
      Conserved Domains (2) summary
      pfam02207
      Location:99166
      zf-UBR; Putative zinc finger in N-recognin (UBR box)
      pfam02617
      Location:222300
      ClpS; ATP-dependent Clp protease adaptor protein ClpS

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      47239217..47321812 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524145.3XP_006524208.1  E3 ubiquitin-protein ligase UBR2 isoform X2

      Conserved Domains (2) summary
      cd00162
      Location:422527
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:421536
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_030249735.2XP_030105595.1  E3 ubiquitin-protein ligase UBR2 isoform X1

      Conserved Domains (2) summary
      cd00162
      Location:679784
      RING_Ubox; RING-H2 finger (C3H2C3-type) [structural motif]
      cl17238
      Location:678793
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain

    RNA

    1. XR_001782069.3 RNA Sequence