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    Il10rb interleukin 10 receptor, beta [ Mus musculus (house mouse) ]

    Gene ID: 16155, updated on 3-Dec-2024

    Summary

    Official Symbol
    Il10rbprovided by MGI
    Official Full Name
    interleukin 10 receptor, betaprovided by MGI
    Primary source
    MGI:MGI:109380
    See related
    Ensembl:ENSMUSG00000022969 AllianceGenome:MGI:109380
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crfb4; CRF2-4; Il10r2; D21S58h; IL-10R2; D16H21S58; 6620401D04Rik
    Summary
    Enables interleukin-10 receptor activity. Predicted to be involved in interleukin-10-mediated signaling pathway; positive regulation of cellular respiration; and positive regulation of receptor signaling pathway via JAK-STAT. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in graft-versus-host disease; hepatitis B; and inflammatory bowel disease 25. Orthologous to human IL10RB (interleukin 10 receptor subunit beta). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 39.0), heart adult (RPKM 34.7) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Il10rb in Genome Data Viewer
    Location:
    16 C3.3; 16 52.87 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91203166..91222718)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91406157..91425834)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24695 Neighboring gene STARR-positive B cell enhancer ABC_E4189 Neighboring gene predicted gene, 36587 Neighboring gene interferon (alpha and beta) receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E7473 Neighboring gene STARR-positive B cell enhancer ABC_E7474 Neighboring gene STARR-positive B cell enhancer ABC_E3171 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91433882-91434035 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91442739-91442929 Neighboring gene STARR-positive B cell enhancer ABC_E10923 Neighboring gene STARR-positive B cell enhancer ABC_E9937 Neighboring gene STARR-positive B cell enhancer ABC_E10924 Neighboring gene RIKEN cDNA A930006K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E3172 Neighboring gene predicted gene, 46562

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables interleukin-10 receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cytokine-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in interleukin-10-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of cellular respiration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of receptor signaling pathway via JAK-STAT ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    IL-10 receptor subunit beta
    IL-10R subunit 2
    IL-10R subunit beta
    IL-10RB
    cytokine receptor class-II member 4
    cytokine receptor family 2 member 4
    cytokine receptor family II, member 4
    interleukin 10 receptor 2
    interleukin-10 receptor subunit 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001405058.1NP_001391987.1  interleukin-10 receptor subunit beta isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC152503
      UniProtKB/Swiss-Prot
      Q61190
      UniProtKB/TrEMBL
      Q3TU35
    2. NM_001405059.1NP_001391988.1  interleukin-10 receptor subunit beta isoform 3 precursor

      Status: VALIDATED

      Source sequence(s)
      AC152503
      Related
      ENSMUST00000152729.8
    3. NM_001405060.1NP_001391989.1  interleukin-10 receptor subunit beta isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC152503
    4. NM_001405062.1NP_001391991.1  interleukin-10 receptor subunit beta isoform 5 precursor

      Status: VALIDATED

      Source sequence(s)
      AC152503
    5. NM_008349.6NP_032375.2  interleukin-10 receptor subunit beta isoform 1 precursor

      See identical proteins and their annotated locations for NP_032375.2

      Status: VALIDATED

      Source sequence(s)
      AC152503
      Consensus CDS
      CCDS37398.1
      UniProtKB/Swiss-Prot
      Q61190
      UniProtKB/TrEMBL
      Q8VHM7
      Related
      ENSMUSP00000023691.6, ENSMUST00000023691.12
      Conserved Domains (2) summary
      pfam09294
      Location:113214
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:23102
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RNA

    1. NR_175904.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC152503
    2. NR_175905.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC152503
    3. NR_175906.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC152503
    4. NR_175907.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC152503
    5. NR_175908.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC152503

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91203166..91222718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)