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    Lonrf2 LON peptidase N-terminal domain and ring finger 2 [ Mus musculus (house mouse) ]

    Gene ID: 381338, updated on 9-Dec-2024

    Summary

    Official Symbol
    Lonrf2provided by MGI
    Official Full Name
    LON peptidase N-terminal domain and ring finger 2provided by MGI
    Primary source
    MGI:MGI:1920209
    See related
    Ensembl:ENSMUSG00000048814 AllianceGenome:MGI:1920209
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2900060P06Rik
    Summary
    Predicted to enable ubiquitin protein ligase activity. Is expressed in central nervous system; ganglia; and neural retina. Orthologous to human LONRF2 (LON peptidase N-terminal domain and ring finger 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 27.9), whole brain E14.5 (RPKM 19.4) and 8 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Lonrf2 in Genome Data Viewer
    Location:
    1 B; 1 17.17 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (38832750..38875768, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (38793669..38836687, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene AF4/FMR2 family, member 3 Neighboring gene STARR-seq mESC enhancer starr_00698 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38714500-38714733 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38721813-38722000 Neighboring gene predicted gene, 34596 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38752992-38753101 Neighboring gene predicted gene, 57569 Neighboring gene STARR-seq mESC enhancer starr_00700 Neighboring gene STARR-positive B cell enhancer ABC_E8770 Neighboring gene STARR-seq mESC enhancer starr_00701 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:38942945-38943098 Neighboring gene carbohydrate sulfotransferase 10 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    LON peptidase N-terminal domain and RING finger protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001029878.2NP_001025049.2  LON peptidase N-terminal domain and RING finger protein 2

      Status: VALIDATED

      Source sequence(s)
      AC124699
      Consensus CDS
      CCDS14900.2
      UniProtKB/TrEMBL
      F6ZE64
      Related
      ENSMUSP00000117600.3, ENSMUST00000147695.9
      Conserved Domains (5) summary
      sd00006
      Location:223253
      TPR; TPR repeat [structural motif]
      pfam02190
      Location:538738
      LON_substr_bdg; ATP-dependent protease La (LON) substrate-binding domain
      cd16513
      Location:136161
      RING1-HC_LONFs; RING finger 1, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
      cd16514
      Location:446487
      RING2-HC_LONFs; RING finger 2, HC subclass, found in the LON peptidase N-terminal domain and RING finger proteins family
      pfam13432
      Location:2790
      TPR_16; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      38832750..38875768 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028403.1: Suppressed sequence

      Description
      NM_028403.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: LONRF2 (GeneID:164832).