Serinc5 serine incorporator 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Serinc5provided by MGI
Official Full Name: serine incorporator 5provided by MGI
Primary source: MGI:MGI:2444223
See related: Ensembl:ENSMUSG00000021703 AllianceGenome:MGI:2444223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: TPO1; AIGP3; A130038L21Rik
Summary: Acts upstream of or within myelination. Located in Golgi apparatus and myelin sheath. Is expressed in several structures, including central nervous system; forelimb; phalanx; retina; and tooth. Orthologous to human SERINC5 (serine incorporator 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thymus adult (RPKM 31.9), ovary adult (RPKM 22.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 C3; 13 47.75 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (92747646..92848455)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (92611138..92711947)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SERINC5 Potently Restricts Retrovirus Infection In Vivo.
Title: SERINC5 Potently Restricts Retrovirus Infection In Vivo.
Study shows that glycoGag interacts with Ser5 in live cells and internalizes Ser5 via receptor-mediated endocytosis. Ser5 is polyubiquitinated and relocalized to endosomes and lysosomes for massive destruction. In addition to the previously identified tyrosine-based sorting signal, results find two more important residues for Ser5 relocalization and downregulation.
Title: Murine Leukemia Virus Glycosylated Gag Reduces Murine SERINC5 Protein Expression at Steady-State Levels via the Endosome/Lysosome Pathway to Counteract SERINC5 Antiretroviral Activity.
TPO1 may play role in myelin formation via Fyn kinase activation in central and peripheral nervous systems.
Title: Identification and functional characterization of mouse TPO1 as a myelin membrane protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Gene trapped (1)

General gene information

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Markers

Serinc5 (e-PCR), detects polymorphism
- UniSTS:498446

23.MHAa90f11.seq (e-PCR)
- UniSTS:123587

C86123 (e-PCR)
- UniSTS:165835

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables acetyltransferase activator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in detection of virus	ISO Inferred from Sequence Orthology more info
involved_in detection of virus	ISS Inferred from Sequence or Structural Similarity more info
involved_in innate immune response	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within myelination	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylserine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in myelin sheath	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: serine incorporator 5

Names: AIGP-3; axotomy-induced glycoprotein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.