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    Rufy1 RUN and FYVE domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 216724, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rufy1provided by MGI
    Official Full Name
    RUN and FYVE domain containing 1provided by MGI
    Primary source
    MGI:MGI:2429762
    See related
    Ensembl:ENSMUSG00000020375 AllianceGenome:MGI:2429762
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rabip4; ZFYVE12; 3000002E04Rik
    Summary
    Predicted to enable identical protein binding activity; protein domain specific binding activity; and protein-macromolecule adaptor activity. Acts upstream of or within protein transport; regulation of endocytosis; and small GTPase-mediated signal transduction. Located in cytoplasm. Is expressed in brain; genitourinary system; heart; liver; and lung. Orthologous to human RUFY1 (RUN and FYVE domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 5.9), adrenal adult (RPKM 5.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rufy1 in Genome Data Viewer
    Location:
    11 B1.3; 11 30.57 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (50280113..50322101, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (50389286..50431274, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6978 Neighboring gene predicted gene, 53701 Neighboring gene microRNA 804 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:50190892-50191075 Neighboring gene STARR-positive B cell enhancer ABC_E2985 Neighboring gene chibby family member 3 Neighboring gene heterogeneous nuclear ribonucleoprotein H1 Neighboring gene STARR-positive B cell enhancer ABC_E2986 Neighboring gene STARR-positive B cell enhancer ABC_E5222 Neighboring gene predicted gene, 53702 Neighboring gene predicted gene, 36763

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Role of the FYVE finger and the RUN domain for the subcellular localization of Rabip4. Mari M, et al. J Biol Chem, 2001 Nov 9. PMID 11509568
    2. 5' UTR variants in the quantitative trait gene Hnrnph1 support reduced 5' UTR usage and hnRNP H protein as a molecular mechanism underlying reduced methamphetamine sensitivity. Ruan QT, et al. FASEB J, 2020 Jul. PMID 32401417, Free PMC Article
    3. Hnrnph1 Is A Quantitative Trait Gene for Methamphetamine Sensitivity. Yazdani N, et al. PLoS Genet, 2015 Dec. PMID 26658939, Free PMC Article
    4. The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes. Mari M, et al. J Cell Sci, 2006 Apr 1. PMID 16522682
    5. The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts. Vukmirica J, et al. J Biol Chem, 2006 Nov 24. PMID 17001082

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rabip4 plays a role in the endocytotic trafficking of Glut4 in 3T3-L1 adipocytes.
      Title: The Rab4 effector Rabip4 plays a role in the endocytotic trafficking of Glut 4 in 3T3-L1 adipocytes.
    2. Rabip4s, possibly via their interaction with Rab4, regulate integrin trafficking and are involved in the migration of NIH 3T3 fibroblasts
      Title: The Rab4A effector protein Rabip4 is involved in migration of NIH 3T3 fibroblasts.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables SH2 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH2 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables SH3 domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in early endosome to Golgi transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in early endosome to Golgi transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal vesicle fusion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endosomal vesicle fusion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of endocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within small GTPase-mediated signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT located_in late endosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    RUN and FYVE domain-containing protein 1
    Names
    FYVE-finger containing protein
    Rab4a interacting protein
    rab4-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172557.3 → NP_766145.1  RUN and FYVE domain-containing protein 1

      See identical proteins and their annotated locations for NP_766145.1

      Status: VALIDATED

      Source sequence(s)
      AK046625, AK046633, BQ176179
      Consensus CDS
      CCDS24635.1
      UniProtKB/Swiss-Prot
      Q8BIJ7, Q8BKQ4, Q8BL21, Q9EPM6
      Related
      ENSMUSP00000020643.4, ENSMUST00000020643.4
      Conserved Domains (3) summary
      cd15758
      Location:638 → 708
      FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
      pfam02759
      Location:151 → 274
      RUN; RUN domain
      cl02073
      Location:444 → 589
      DUF3422; Protein of unknown function (DUF3422)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      50280113..50322101 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532841.5 → XP_006532904.1  RUN and FYVE domain-containing protein 1 isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:237 → 540
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      cd15758
      Location:545 → 615
      FYVE_RUFY1; FYVE domain found in RUN and FYVE domain-containing protein 1 (RUFY1) and similar proteins
      pfam02759
      Location:58 → 179
      RUN; RUN domain

    2. XM_017314442.2 → XP_017169931.1  RUN and FYVE domain-containing protein 1 isoform X2

      Conserved Domains (1) summary
      pfam02759
      Location:151 → 272
      RUN; RUN domain

    RNA

    1. XR_001779949.2 RNA Sequence

    2. XR_004936914.1 RNA Sequence

    3. XR_004936913.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIJ7.1 GenPept UniProtKB/Swiss-Prot:Q8BIJ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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