Ppif peptidylprolyl isomerase F (cyclophilin F) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppifprovided by MGI
Official Full Name: peptidylprolyl isomerase F (cyclophilin F)provided by MGI
Primary source: MGI:MGI:2145814
See related: Ensembl:ENSMUSG00000021868 AllianceGenome:MGI:2145814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: CypD; CyP-D; CyP-F; PPIase
Summary: Predicted to enable cyclosporin A binding activity; peptide binding activity; and peptidyl-prolyl cis-trans isomerase activity. Involved in several processes, including regulation of mitochondrial membrane permeability involved in programmed necrotic cell death; regulation of proton transport; and response to ischemia. Acts upstream of or within several processes, including apoptotic mitochondrial changes; mitochondrial depolarization; and skeletal muscle fiber differentiation. Located in mitochondrion. Part of mitochondrial permeability transition pore complex. Is expressed in lower jaw tooth and tooth. Orthologous to human PPIF (peptidylprolyl isomerase F). [provided by Alliance of Genome Resources, Dec 2024]
Annotation information: Note: This gene encodes a 177 aa mature peptide that is found in the mitochondrion. It has been labeled 'cyclophilin D'. This same name has also been applied to a different cytoplasmic protein of 370 aa, which is represented by Entrez GeneID 67738, Ppid. [09 Apr 2019]
Expression: Broad expression in stomach adult (RPKM 120.1), colon adult (RPKM 89.7) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 A3; 14 15.06 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (25693998..25700892)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (25693574..25700468)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair.
Title: Cyclophilin D, regulator of the mitochondrial permeability transition, impacts bone development and fracture repair.
Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.
Title: Mitochondrial CypD Acetylation Promotes Endothelial Dysfunction and Hypertension.
Role of the mitochondrial protein cyclophilin D in skin wound healing and collagen secretion.
Title: Role of the mitochondrial protein cyclophilin D in skin wound healing and collagen secretion.
Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH.
Title: Cyclophilin D knockout significantly prevents HCC development in a streptozotocin-induced mouse model of diabetes-linked NASH.
Constitutive cyclophilin-D ablation in mice increases exercise and cognitive-behavioral performance under normoxic and hypoxic conditions.
Title: Constitutive cyclophilin-D ablation in mice increases exercise and cognitive-behavioral performance under normoxic and hypoxic conditions.
Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Title: Regulation of NETosis and Inflammation by Cyclophilin D in Myeloperoxidase-Positive Antineutrophil Cytoplasmic Antibody-Associated Vasculitis.
Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3alpha, improves sperm motility.
Title: Inhibition of mitochondrial cyclophilin D, a downstream target of glycogen synthase kinase 3α, improves sperm motility.
CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway.
Title: CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway.
MicroRNA-155-5p in serum derived-exosomes promotes ischaemia-reperfusion injury by reducing CypD ubiquitination by NEDD4.
Title: MicroRNA-155-5p in serum derived-exosomes promotes ischaemia-reperfusion injury by reducing CypD ubiquitination by NEDD4.
CypD-mediated mitochondrial dysfunction contributes to titanium ion-induced MC3T3-E1 cell injury.
Title: CypD-mediated mitochondrial dysfunction contributes to titanium ion-induced MC3T3-E1 cell injury.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA polymerase II CTD heptapeptide repeat P3 isomerase activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat P6 isomerase activity	IEA Inferred from Electronic Annotation more info
enables cyclosporin A binding	IBA Inferred from Biological aspect of Ancestor more info
enables cyclosporin A binding	IEA Inferred from Electronic Annotation more info
enables cyclosporin A binding	ISO Inferred from Sequence Orthology more info
enables peptide binding	IEA Inferred from Electronic Annotation more info
enables peptide binding	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptidyl-prolyl cis-trans isomerase activity	ISO Inferred from Sequence Orthology more info
enables peptidyl-prolyl cis-trans isomerase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptidyl-prolyl cis-trans isomerase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic mitochondrial changes	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to arsenic-containing substance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitochondrial depolarization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in mitochondrial outer membrane permeabilization involved in programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial outer membrane permeabilization involved in programmed cell death	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitochondrion organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within muscle structure development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of ATP-dependent activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of oxidative phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of oxidative phosphorylation uncoupler activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of release of cytochrome c from mitochondria	ISS Inferred from Sequence or Structural Similarity more info
involved_in programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein peptidyl-prolyl isomerization	ISO Inferred from Sequence Orthology more info
involved_in protein peptidyl-prolyl isomerization	TAS Traceable Author Statement more info	PubMed
involved_in regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of mitochondrial membrane permeability	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitochondrial membrane permeability	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mitochondrial membrane permeability involved in programmed necrotic cell death	ISO Inferred from Sequence Orthology more info
involved_in regulation of proton-transporting ATPase activity, rotational mechanism	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within skeletal muscle fiber differentiation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of mitochondrial permeability transition pore complex	ISO Inferred from Sequence Orthology more info
part_of mitochondrial permeability transition pore complex	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial permeability transition pore complex	TAS Traceable Author Statement more info	PubMed
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptidyl-prolyl cis-trans isomerase F, mitochondrial

Names: PPIase F; cyclophilin D; cyclophilin F; mitochondrial Cyclophilin D; peptidyl-prolyl cis-trans isomerase, mitochondrial; rotamase F

NP_598845.1

EC 5.2.1.8

XP_017171263.1

EC 5.2.1.8

XP_030103456.1

EC 5.2.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134084.1 → NP_598845.1 peptidyl-prolyl cis-trans isomerase F, mitochondrial precursor

See identical proteins and their annotated locations for NP_598845.1

Status: PROVISIONAL

Source sequence(s)

BC004041

Consensus CDS

CCDS26874.1

UniProtKB/Swiss-Prot

Q99KR7

Related

ENSMUSP00000022419.7, ENSMUST00000022419.7

Conserved Domains (1) summary

cd01926
Location:45 → 203

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

25693998..25700892

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030247596.1 → XP_030103456.1 peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X1

UniProtKB/Swiss-Prot

Q99KR7

Conserved Domains (1) summary

cd01926
Location:45 → 203

cyclophilin_ABH_like; Cyclophilin A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which accelerates protein folding ...
XM_017315774.2 → XP_017171263.1 peptidyl-prolyl cis-trans isomerase F, mitochondrial isoform X2

Conserved Domains (1) summary

cl00197
Location:45 → 104

cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...