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    Ctnna3 catenin alpha 3 [ Mus musculus (house mouse) ]

    Gene ID: 216033, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ctnna3provided by MGI
    Official Full Name
    catenin alpha 3provided by MGI
    Primary source
    MGI:MGI:2661445
    See related
    Ensembl:ENSMUSG00000060843 AllianceGenome:MGI:2661445
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Vr22; Catna3; 4933408A16; 4930429L08Rik
    Summary
    Predicted to enable actin filament binding activity and beta-catenin binding activity. Involved in cell-cell adhesion. Located in adherens junction; fascia adherens; and lamellipodium. Is expressed in cardiac muscle tissue and skin of male preputial swelling. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular dysplasia 13. Orthologous to human CTNNA3 (catenin alpha 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in testis adult (RPKM 9.1), heart adult (RPKM 3.0) and 1 other tissue See more
    Orthologs
    human all
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    Genomic context

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    See Ctnna3 in Genome Data Viewer
    Location:
    10 B4- B5.1; 10 32.57 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63265877..64841174)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63430098..65003667)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2940 Neighboring gene STARR-positive B cell enhancer ABC_E1121 Neighboring gene nuclear encoded tRNA serine 3 (anticodon TGA) Neighboring gene ring finger protein 7 like Neighboring gene STARR-seq mESC enhancer starr_26935 Neighboring gene STARR-seq mESC enhancer starr_26936 Neighboring gene predicted gene, 30644 Neighboring gene STARR-seq mESC enhancer starr_26937 Neighboring gene leucine rich repeat transmembrane neuronal 3 Neighboring gene STARR-seq mESC enhancer starr_26939 Neighboring gene STARR-seq mESC enhancer starr_26940 Neighboring gene STARR-seq mESC enhancer starr_26941 Neighboring gene STARR-seq mESC enhancer starr_26942 Neighboring gene STARR-seq mESC enhancer starr_26944 Neighboring gene STARR-seq mESC enhancer starr_26945 Neighboring gene STARR-seq mESC enhancer starr_26947 Neighboring gene STARR-seq mESC enhancer starr_26948 Neighboring gene STARR-seq mESC enhancer starr_26949 Neighboring gene predicted gene, 51834 Neighboring gene predicted gene 28881

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The cardiac protein αT-catenin contributes to chemical-induced asthma. Folmsbee SS, et al. Am J Physiol Lung Cell Mol Physiol, 2015 Feb 1. PMID 25480337, Free PMC Article
    2. Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions. Weng A, et al. Biol Open, 2022 Dec 15. PMID 36420826, Free PMC Article
    3. The cardiomyocyte protein αT-catenin contributes to asthma through regulating pulmonary vein inflammation. Folmsbee SS, et al. J Allergy Clin Immunol, 2016 Jul. PMID 26947180, Free PMC Article
    4. αT-catenin in restricted brain cell types and its potential connection to autism. Folmsbee SS, et al. J Mol Psychiatry, 2016. PMID 27330745, Free PMC Article
    5. Truncated isoform of mouse alphaT-catenin is testis-restricted in expression and function. Goossens S, et al. FASEB J, 2007 Mar. PMID 17185752

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions.
      Title: Alpha-T-catenin is expressed in peripheral nerves as a constituent of Schwann cell adherens junctions.
    2. SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
      Title: SPATA33 affects the formation of cell adhesion complex by interacting with CTNNA3 in TM4 cells.
    3. Unravelling the ultrastructural details of alphaT-catenin-deficient cell-cell contacts between heart muscle cells by the use of FIB-SEM.
      Title: Unravelling the ultrastructural details of αT-catenin-deficient cell-cell contacts between heart muscle cells by the use of FIB-SEM.
    4. alpha-catenins regulate intercalated disc maturation and actomyosin contractility, which, in turn, control Yap subcellular localization, thus providing an explanation for the loss of proliferative capacity in the newborn mammalian heart.
      Title: α-Catenin-dependent cytoskeletal tension controls Yap activity in the heart.
    5. AlphaT-catenin may contribute to asthma through a mechanism independent of inflammation and related to heart and pulmonary vein dysfunction.
      Title: The cardiac protein αT-catenin contributes to chemical-induced asthma.
    6. alphaT-catenin-null mice are viable and fertile; however, the animals exhibit progressive cardiomyopathy
      Title: Loss of αT-catenin alters the hybrid adhering junctions in the heart and leads to dilated cardiomyopathy and ventricular arrhythmia following acute ischemia.
    7. study suggests a pivotal role of alphaT-catenin levels in the control of the proliferative versus invasive state of trophoblasts during placentation
      Title: Tissue-wide overexpression of alpha-T-catenin results in aberrant trophoblast invasion but does not cause embryonic mortality in mice.
    8. By providing an extra link between the cadherin-catenin complex and intermediate filaments, the binding of alphaT-catenin to plakophilin-2 is proposed to be a means of modulating and strengthening cell-cell adhesion between cardiac muscle cells.
      Title: A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-catenin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables beta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cadherin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of heart rate by cardiac conduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of ventricular cardiac muscle cell action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in desmosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in fascia adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in fascia adherens IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in fascia adherens ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in fascia adherens ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    catenin alpha-3
    Names
    alpha T-catenin
    alpha-catenin-like protein
    alphaT-catenin
    cadherin-associated protein
    catenin (cadherin associated protein), alpha 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164376.1 → NP_001157848.1  catenin alpha-3 isoform 1

      See identical proteins and their annotated locations for NP_001157848.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AK142745
      Consensus CDS
      CCDS23901.1
      UniProtKB/Swiss-Prot
      Q3UQ61, Q65CL1, Q8C0N3
      UniProtKB/TrEMBL
      A4GE64
      Related
      ENSMUSP00000101080.2, ENSMUST00000105440.8
      Conserved Domains (1) summary
      pfam01044
      Location:18 → 856
      Vinculin; Vinculin family

    2. NM_001164519.1 → NP_001157991.1  catenin alpha-3 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AC113544, AC153511, AC153513, AC153514, AC153926, AC158604, AC158638, AC158806
      UniProtKB/TrEMBL
      A4GE65
      Conserved Domains (1) summary
      pfam01044
      Location:15 → 589
      Vinculin; Vinculin family

    3. NM_177612.3 → NP_808280.2  catenin alpha-3 isoform 1

      See identical proteins and their annotated locations for NP_808280.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AC153513, AK030166, AK142745
      Consensus CDS
      CCDS23901.1
      UniProtKB/Swiss-Prot
      Q3UQ61, Q65CL1, Q8C0N3
      UniProtKB/TrEMBL
      A4GE64
      Related
      ENSMUSP00000101081.2, ENSMUST00000105441.8
      Conserved Domains (1) summary
      pfam01044
      Location:18 → 856
      Vinculin; Vinculin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      63265877..64841174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513475.4 → XP_006513538.1  catenin alpha-3 isoform X1

      See identical proteins and their annotated locations for XP_006513538.1

      UniProtKB/Swiss-Prot
      Q3UQ61, Q65CL1, Q8C0N3
      UniProtKB/TrEMBL
      A4GE64
      Conserved Domains (1) summary
      pfam01044
      Location:18 → 856
      Vinculin; Vinculin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q65CL1.2 GenPept UniProtKB/Swiss-Prot:Q65CL1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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