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    Ttc1 tetratricopeptide repeat domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 66827, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ttc1provided by MGI
    Official Full Name
    tetratricopeptide repeat domain 1provided by MGI
    Primary source
    MGI:MGI:1914077
    See related
    Ensembl:ENSMUSG00000041278 AllianceGenome:MGI:1914077
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TPR1; 4833412C19Rik
    Summary
    Predicted to be located in cytosol. Orthologous to human TTC1 (tetratricopeptide repeat domain 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.8), bladder adult (RPKM 16.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ttc1 in Genome Data Viewer
    Location:
    11 B1.1; 11 25.81 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43620833..43638835, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43730006..43748008, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_29265 Neighboring gene STARR-positive B cell enhancer ABC_E75 Neighboring gene 40S ribosomal protein S2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_29267 Neighboring gene predicted gene, 34963 Neighboring gene PWWP domain containing 2A Neighboring gene STARR-seq mESC enhancer starr_29268 Neighboring gene STARR-positive B cell enhancer ABC_E1414 Neighboring gene adrenergic receptor, alpha 1b Neighboring gene STARR-seq mESC enhancer starr_29271 Neighboring gene predicted gene 12153

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. High-throughput mapping of a dynamic signaling network in mammalian cells. Barrios-Rodiles M, et al. Science, 2005 Mar 11. PMID 15761153
    2. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    3. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
    5. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat protein 1
    Names
    TPR repeat protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133795.2 → NP_598556.1  tetratricopeptide repeat protein 1

      See identical proteins and their annotated locations for NP_598556.1

      Status: VALIDATED

      Source sequence(s)
      AL669911, AL732633
      Consensus CDS
      CCDS24561.1
      UniProtKB/Swiss-Prot
      Q3TLM0, Q91Z38
      UniProtKB/TrEMBL
      Q3TDF3
      Related
      ENSMUSP00000040779.3, ENSMUST00000048578.3
      Conserved Domains (4) summary
      smart00028
      Location:189 → 221
      TPR; Tetratricopeptide repeats
      sd00006
      Location:119 → 144
      TPR; TPR repeat [structural motif]
      pfam00515
      Location:158 → 188
      TPR_1; Tetratricopeptide repeat
      pfam13414
      Location:119 → 186
      TPR_11; TPR repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      43620833..43638835 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91Z38.1 GenPept UniProtKB/Swiss-Prot:Q91Z38

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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