Ccnq cyclin Q [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ccnqprovided by MGI
Official Full Name: cyclin Qprovided by MGI
Primary source: MGI:MGI:1916359
See related: Ensembl:ENSMUSG00000049489 AllianceGenome:MGI:1916359
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam58a; Fam58b; 1810009O10Rik
Summary: Enables protein kinase activator activity. Acts upstream of or within positive regulation of MAPK cascade. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in nucleus. Is expressed in several structures, including adrenal gland; central nervous system; heart; pancreas; and retina. Human ortholog(s) of this gene implicated in syndactyly-telecanthus-anogenital and renal malformations syndrome. Orthologous to human CCNQ (cyclin Q). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78641332..78642555, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78750506..78751729, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cyclin-dependent protein serine/threonine kinase regulator activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell cycle G2/M phase transition	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle G2/M phase transition	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of cyclin-dependent protein kinase holoenzyme complex	ISO Inferred from Sequence Orthology more info
part_of cyclin-dependent protein kinase holoenzyme complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cyclin-Q

Names: CDK10-activating cyclin; cyclin M; cyclin-related protein FAM58A; cyclin-related protein FAM58B; family with sequence similarity 58, member B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_197989.1 → NP_932106.1 cyclin-Q

See identical proteins and their annotated locations for NP_932106.1

Status: VALIDATED

Source sequence(s)

BC027022

Consensus CDS

CCDS25114.1

UniProtKB/Swiss-Prot

Q8QZR8

Related

ENSMUSP00000050658.5, ENSMUST00000059468.6

Conserved Domains (2) summary

COG5333
Location:35 → 248

CCL1; Cdk activating kinase (CAK)/RNA polymerase II transcription initiation/nucleotide excision repair factor TFIIH/TFIIK, cyclin H subunit [Cell division and chromosome partitioning / Transcription / DNA replication, recombination, and repair]

cd00043
Location:34 → 131

CYCLIN; Cyclin box fold. Protein binding domain functioning in cell-cycle and transcription control. Present in cyclins, TFIIB and Retinoblastoma (RB).The cyclins consist of 8 classes of cell cycle regulators that regulate cyclin dependent kinases (CDKs). TFIIB ...