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    Arfip1 ARF interacting protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 99889, updated on 9-Dec-2024

    Summary

    Official Symbol
    Arfip1provided by MGI
    Official Full Name
    ARF interacting protein 1provided by MGI
    Primary source
    MGI:MGI:1277120
    See related
    Ensembl:ENSMUSG00000074513 Ensembl:ENSMUSG00000102805 AllianceGenome:MGI:1277120
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arfaptin; D3Ertd598e; 2310030I10Rik
    Summary
    Predicted to enable phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in intracellular protein transport; negative regulation of retrograde transport, endosome to Golgi; and regulation of Arp2/3 complex-mediated actin nucleation. Predicted to act upstream of or within regulation of protein secretion. Predicted to be located in Golgi membrane and cytosol. Predicted to be active in trans-Golgi network membrane. Orthologous to human ARFIP1 (ADP ribosylation factor interacting protein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 12.6), placenta adult (RPKM 11.4) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arfip1 in Genome Data Viewer
    Location:
    3 F1; 3 37.7 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (84403400..84490075, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (84496093..84582751, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930565D16 gene Neighboring gene STARR-seq mESC enhancer starr_08085 Neighboring gene FH2 domain containing 1 Neighboring gene STARR-positive B cell enhancer mm9_chr3:84346416-84346716 Neighboring gene high mobility group box 3 pseudogene Neighboring gene predicted gene, 35410 Neighboring gene tigger transposable element derived 4 Neighboring gene predicted gene, 46836

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables phosphatidylinositol-4-phosphate binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in trans-Golgi network membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in trans-Golgi network membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    arfaptin-1
    Names
    ADP-ribosylation factor interacting protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081093.2NP_001074562.1  arfaptin-1 isoform 1

      See identical proteins and their annotated locations for NP_001074562.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC102224
      Consensus CDS
      CCDS38466.1
      UniProtKB/Swiss-Prot
      A2RSX9, E9Q3G5, G5E8V9
      Related
      ENSMUSP00000122964.2, ENSMUST00000143514.3
      Conserved Domains (1) summary
      cd07660
      Location:155355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    2. NM_001293801.1NP_001280730.1  arfaptin-1 isoform 2

      See identical proteins and their annotated locations for NP_001280730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC102224
      Consensus CDS
      CCDS79931.1
      UniProtKB/TrEMBL
      A2RSX9
      Related
      ENSMUSP00000096588.4, ENSMUST00000098990.10
      Conserved Domains (1) summary
      cd07660
      Location:123323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      84403400..84490075 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502484.4XP_006502547.1  arfaptin-1 isoform X3

      UniProtKB/TrEMBL
      E9QAY5, Q3TVE1
      Related
      ENSMUSP00000116393.2, ENSMUST00000154148.8
      Conserved Domains (1) summary
      cd07660
      Location:34234
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    2. XM_036163483.1XP_036019376.1  arfaptin-1 isoform X2

      Conserved Domains (1) summary
      cd07660
      Location:123323
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin
    3. XM_006502482.4XP_006502545.1  arfaptin-1 isoform X1

      See identical proteins and their annotated locations for XP_006502545.1

      UniProtKB/Swiss-Prot
      A2RSX9, E9Q3G5, G5E8V9
      Conserved Domains (1) summary
      cd07660
      Location:155355
      BAR_Arfaptin; The Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin