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    Ptpn14 protein tyrosine phosphatase, non-receptor type 14 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 305064, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ptpn14provided by RGD
    Official Full Name
    protein tyrosine phosphatase, non-receptor type 14provided by RGD
    Primary source
    RGD:1307885
    See related
    EnsemblRapid:ENSRNOG00000003407 AllianceGenome:RGD:1307885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable protein tyrosine phosphatase activity; receptor tyrosine kinase binding activity; and transcription coregulator activity. Predicted to be involved in lymphangiogenesis; negative regulation of cell population proliferation; and regulation of protein export from nucleus. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human PTPN14 (protein tyrosine phosphatase non-receptor type 14). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 76.4), Lung (RPKM 62.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ptpn14 in Genome Data Viewer
    Location:
    13q26
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (103799473..103951708)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (101268258..101420508)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (108689916..108841593, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 2 Neighboring gene wiskott-Aldrich syndrome protein homolog 1-like Neighboring gene centromere protein F Neighboring gene SET and MYND domain containing 2 Neighboring gene uncharacterized LOC134481544 Neighboring gene uncharacterized LOC134481634

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. Wadham C, et al. J Cell Sci, 2000 Sep. PMID 10934049
    2. PTPN14 interacts with and negatively regulates the oncogenic function of YAP. Liu X, et al. Oncogene, 2013 Mar 7. PMID 22525271, Free PMC Article
    3. Protein tyrosine phosphatase PTPN14 is a regulator of lymphatic function and choanal development in humans. Au AC, et al. Am J Hum Genet, 2010 Sep 10. PMID 20826270, Free PMC Article
    4. PTPN14 is required for the density-dependent control of YAP1. Wang W, et al. Genes Dev, 2012 Sep 1. PMID 22948661, Free PMC Article
    5. FMRP recruitment of β-catenin to the translation pre-initiation complex represses translation. Ehyai S, et al. EMBO Rep, 2018 Dec. PMID 30361391, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone H2AXY142 phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables non-membrane spanning protein tyrosine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tyrosine phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein tyrosine phosphatase activity, metal-dependent IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables receptor tyrosine kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lymphangiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lymphangiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of protein export from nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tyrosine-protein phosphatase non-receptor type 14
    NP_001388293.1
    XP_017454326.1
    XP_038946755.1
    XP_038946756.1
    XP_038946757.1
    XP_063128460.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401364.1 → NP_001388293.1  tyrosine-protein phosphatase non-receptor type 14

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A0G2K2N0
      Related
      ENSRNOP00000072308.1, ENSRNOT00000086775.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      103799473..103951708
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017598837.3 → XP_017454326.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2N0, A0A8I5ZVY1
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
      cl17171
      Location:215 → 305
      PH-like; Pleckstrin homology-like domain

    2. XM_039090828.2 → XP_038946756.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2N0, A0A8I5ZVY1
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
      cl17171
      Location:215 → 305
      PH-like; Pleckstrin homology-like domain

    3. XM_039090827.2 → XP_038946755.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2N0, A0A8I5ZVY1
      Conserved Domains (3) summary
      smart00295
      Location:24 → 220
      B41; Band 4.1 homologues
      cd14599
      Location:898 → 1184
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
      cl17171
      Location:215 → 305
      PH-like; Pleckstrin homology-like domain

    4. XM_063272390.1 → XP_063128460.1  tyrosine-protein phosphatase non-receptor type 14 isoform X1

      UniProtKB/TrEMBL
      A0A0G2K2N0

    5. XM_039090829.2 → XP_038946757.1  tyrosine-protein phosphatase non-receptor type 14 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZVY1
      Conserved Domains (3) summary
      cd14599
      Location:729 → 1015
      PTPc-N14; catalytic domain of tyrosine-protein phosphatase non-receptor type 14
      cl09511
      Location:1 → 51
      FERM_B-lobe; FERM domain B-lobe
      cl17171
      Location:46 → 136
      PH-like; Pleckstrin homology-like domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001107200.1: Suppressed sequence

      Description
      NM_001107200.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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