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    MED18 mediator complex subunit 18 [ Homo sapiens (human) ]

    Gene ID: 54797, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MED18provided by HGNC
    Official Full Name
    mediator complex subunit 18provided by HGNC
    Primary source
    HGNC:HGNC:25944
    See related
    Ensembl:ENSG00000130772 MIM:612384; AllianceGenome:HGNC:25944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SRB5; p28b
    Summary
    MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
    Expression
    Ubiquitous expression in colon (RPKM 5.4), lymph node (RPKM 4.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See MED18 in Genome Data Viewer
    Location:
    1p35.3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (28329040..28335965)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (28170876..28177801)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (28655551..28662476)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28572195-28572694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 593 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28576752-28577625 Neighboring gene ATP synthase inhibitory factor subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 594 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28585772-28586620 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 537 Neighboring gene sestrin 2 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:28616419-28617413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 595 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:28640148-28640648 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28655585-28656092 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28656093-28656600 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:28695423-28696378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 538 Neighboring gene phosphatase and actin regulator 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:28726665-28726882 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 539 Neighboring gene Sharpr-MPRA regulatory region 2241 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 540 Neighboring gene RNA, U6atac small nuclear 27, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7965 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:28833855-28834620 Neighboring gene small nucleolar RNA, H/ACA box 73A Neighboring gene small nucleolar RNA host gene 3 Neighboring gene regulator of chromosome condensation 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module. Kumafuji M, et al. Genes Cells, 2014 Jul. PMID 24840924
    2. Dermatomyositis presenting with focal scleroderma-like skin changes. Chai Y, et al. J Clin Neuromuscul Dis, 2012 Jun. PMID 22622162
    3. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation. Xuan Y, et al. Cell Death Dis, 2019 Sep 18. PMID 31534128, Free PMC Article
    4. Artificial recruitment of mediator by the DNA-binding domain of Adr1 overcomes glucose repression of ADH2 expression. Young ET, et al. Mol Cell Biol, 2008 Apr. PMID 18250152, Free PMC Article
    5. A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex. Sato S, et al. J Biol Chem, 2003 Dec 12. PMID 14576168

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
      Title: Long non-coding RNA SNHG3 promotes progression of gastric cancer by regulating neighboring MED18 gene methylation.
    2. A novel transcriptional repression mechanism of hMED18 mediated by hCDK8 and further a novel positive role of free CDK/cyclin module in transcriptional activation is described.
      Title: Mediator MED18 subunit plays a negative role in transcription via the CDK/cyclin module.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat 47-59 peptide upregulates gene expression of mediator complex subunit 18 (MED18) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20045

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of core mediator complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 18
    Names
    TRAP/mediator complex subunit p28b
    mediator of RNA polymerase II transcription, subunit 18 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127350.2 → NP_001120822.1  mediator of RNA polymerase II transcription subunit 18

      See identical proteins and their annotated locations for NP_001120822.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL353622, BG752399
      Consensus CDS
      CCDS322.1
      UniProtKB/Swiss-Prot
      D3DPM1, Q9BUE0, Q9NXU9
      UniProtKB/TrEMBL
      B4DJL3
      Conserved Domains (1) summary
      pfam09637
      Location:19 → 207
      Med18; Med18 protein

    2. NM_017638.3 → NP_060108.2  mediator of RNA polymerase II transcription subunit 18

      See identical proteins and their annotated locations for NP_060108.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK000052, AL353622
      Consensus CDS
      CCDS322.1
      UniProtKB/Swiss-Prot
      D3DPM1, Q9BUE0, Q9NXU9
      UniProtKB/TrEMBL
      B4DJL3
      Related
      ENSP00000362948.4, ENST00000373842.9
      Conserved Domains (1) summary
      pfam09637
      Location:19 → 207
      Med18; Med18 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      28329040..28335965
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005245914.5 → XP_005245971.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

      See identical proteins and their annotated locations for XP_005245971.1

      UniProtKB/Swiss-Prot
      D3DPM1, Q9BUE0, Q9NXU9
      UniProtKB/TrEMBL
      B4DJL3
      Conserved Domains (1) summary
      pfam09637
      Location:19 → 207
      Med18; Med18 protein

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654706.1 Reference GRCh38.p14 PATCHES

      Range
      122684..129609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054332155.1 → XP_054188130.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

      UniProtKB/Swiss-Prot
      D3DPM1, Q9BUE0, Q9NXU9
      UniProtKB/TrEMBL
      B4DJL3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      28170876..28177801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054337204.1 → XP_054193179.1  mediator of RNA polymerase II transcription subunit 18 isoform X1

      UniProtKB/Swiss-Prot
      D3DPM1, Q9BUE0, Q9NXU9
      UniProtKB/TrEMBL
      B4DJL3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BUE0.1 GenPept UniProtKB/Swiss-Prot:Q9BUE0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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