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    STK17B serine/threonine kinase 17b [ Homo sapiens (human) ]

    Gene ID: 9262, updated on 10-Dec-2024

    Summary

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    Official Symbol
    STK17Bprovided by HGNC
    Official Full Name
    serine/threonine kinase 17bprovided by HGNC
    Primary source
    HGNC:HGNC:11396
    See related
    Ensembl:ENSG00000081320 MIM:604727; AllianceGenome:HGNC:11396
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DRAK2
    Summary
    Enables ATP binding activity and protein serine/threonine kinase activity. Involved in intracellular signal transduction; positive regulation of fibroblast apoptotic process; and protein phosphorylation. Located in Flemming body and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bone marrow (RPKM 54.0), lymph node (RPKM 45.0) and 18 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See STK17B in Genome Data Viewer
    Location:
    2q32.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (196133583..196176483, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (196617655..196666801, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (196998307..197036302, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene dynein axonemal heavy chain 7 Neighboring gene E2F transcription factor 3 pseudogene 2 Neighboring gene glutathione S-transferase alpha 5 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16892 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:196961660-196962248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16893 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16895 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:196977894-196978422 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:197023734-197024234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16896 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12202 Neighboring gene uncharacterized LOC101927454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12203 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16897 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16898 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16899 Neighboring gene small nucleolar RNA U13 Neighboring gene MPRA-validated peak4000 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16900 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:197124217-197125416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16901 Neighboring gene HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 Neighboring gene HECW2 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia. Szoltysek K, et al. Int J Mol Sci, 2020 Oct 16. PMID 33081245, Free PMC Article
    2. Altered thymic selection and increased autoimmunity caused by ectopic expression of DRAK2 during T cell development. Gatzka M, et al. J Immunol, 2009 Jul 1. PMID 19542440, Free PMC Article
    3. DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor. Yang KM, et al. Cell Rep, 2012 Nov 29. PMID 23122956
    4. DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition. Lu Y, et al. Sci Transl Med, 2024 Feb 7. PMID 38324636
    5. Modulation of DRAK2 autophosphorylation by antigen receptor signaling in primary lymphocytes. Friedrich ML, et al. J Biol Chem, 2007 Feb 16. PMID 17182616

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser[56] to diminish pancreatic beta cell function upon overnutrition.
      Title: DRAK2 suppresses autophagy by phosphorylating ULK1 at Ser(56) to diminish pancreatic β cell function upon overnutrition.
    2. DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
      Title: DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing.
    3. DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.
      Title: DAP Kinase-Related Apoptosis-Inducing Protein Kinase 2 (DRAK2) Is a Key Regulator and Molecular Marker in Chronic Lymphocytic Leukemia.
    4. STK17B promotes carcinogenesis and metastasis via AKT/GSK-3beta/Snail signaling in hepatocellular carcinoma.
      Title: STK17B promotes carcinogenesis and metastasis via AKT/GSK-3β/Snail signaling in hepatocellular carcinoma.
    5. A significant interaction between variants in STK17B and PAX8, in papillary thyroid cancer susceptibility, is reported.
      Title: An epistatic interaction between the PAX8 and STK17B genes in papillary thyroid cancer susceptibility.
    6. ChIP assays showed that in U937 cells MYB binds to a conserved element upstream of the DRAK2 transcription start site.
      Title: The MYB oncogene can suppress apoptosis in acute myeloid leukemia cells by transcriptional repression of DRAK2 expression.
    7. DRAK2 protein directly binds to the type I TGF-beta receptor and Knockdown of DRAK2 suppresses the tumorigenic ability of breast cancer cells.
      Title: DRAK2 participates in a negative feedback loop to control TGF-β/Smads signaling by binding to type I TGF-β receptor.
    8. DRAK2 and protein kinase D form a novel signaling module that controls calcium homeostasis following T cell activation.
      Title: Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.
    9. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of fibroblast apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 17B
    Names
    DAP kinase-related apoptosis-inducing protein kinase 2
    death-associated protein kinase-related 2
    NP_004217.1
    XP_011510471.1
    XP_011510472.1
    XP_011510473.1
    XP_047302289.1
    XP_047302290.1
    XP_047302291.1
    XP_054200533.1
    XP_054200534.1
    XP_054200535.1
    XP_054200536.1
    XP_054200537.1
    XP_054200538.1
    XP_054200539.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_004226.4 → NP_004217.1  serine/threonine-protein kinase 17B

      See identical proteins and their annotated locations for NP_004217.1

      Status: VALIDATED

      Source sequence(s)
      AC114760, BM994696
      Consensus CDS
      CCDS2315.1
      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000263955.4, ENST00000263955.9
      Conserved Domains (1) summary
      cd14198
      Location:24 → 293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      196133583..196176483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011512169.2 → XP_011510471.1  serine/threonine-protein kinase 17B isoform X1

      See identical proteins and their annotated locations for XP_011510471.1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000386853.1, ENST00000409228.5
      Conserved Domains (1) summary
      cd14198
      Location:24 → 293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

    2. XM_011512170.2 → XP_011510472.1  serine/threonine-protein kinase 17B isoform X1

      See identical proteins and their annotated locations for XP_011510472.1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000399755.2, ENST00000420683.2
      Conserved Domains (1) summary
      cd14198
      Location:24 → 293
      STKc_DRAK2; The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2

    3. XM_047446334.1 → XP_047302290.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98

    4. XM_047446333.1 → XP_047302289.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98
      Related
      ENSP00000413289.2, ENST00000449152.2

    5. XM_011512171.3 → XP_011510473.1  serine/threonine-protein kinase 17B isoform X2

      See identical proteins and their annotated locations for XP_011510473.1

      Conserved Domains (2) summary
      smart00220
      Location:3 → 165
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:1 → 165
      PKc_like; Protein Kinases, catalytic domain

    6. XM_047446335.1 → XP_047302291.1  serine/threonine-protein kinase 17B isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      196617655..196666801 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344561.1 → XP_054200536.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98

    2. XM_054344559.1 → XP_054200534.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98

    3. XM_054344560.1 → XP_054200535.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98

    4. XM_054344562.1 → XP_054200537.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98

    5. XM_054344558.1 → XP_054200533.1  serine/threonine-protein kinase 17B isoform X1

      UniProtKB/Swiss-Prot
      O94768
      UniProtKB/TrEMBL
      Q53QE7, Q6FG98

    6. XM_054344563.1 → XP_054200538.1  serine/threonine-protein kinase 17B isoform X2

    7. XM_054344564.1 → XP_054200539.1  serine/threonine-protein kinase 17B isoform X2

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O94768.1 GenPept UniProtKB/Swiss-Prot:O94768

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