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    TMEM177 transmembrane protein 177 [ Homo sapiens (human) ]

    Gene ID: 80775, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TMEM177provided by HGNC
    Official Full Name
    transmembrane protein 177provided by HGNC
    Primary source
    HGNC:HGNC:28143
    See related
    Ensembl:ENSG00000144120 MIM:620752; AllianceGenome:HGNC:28143
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Involved in mitochondrial respiratory chain complex II assembly. Located in mitochondrial inner membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in duodenum (RPKM 5.2), kidney (RPKM 5.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM177 in Genome Data Viewer
    Location:
    2q14.2
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (119679201..119723618)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (120112838..120157662)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (120436777..120481194)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120238515-120239026 Neighboring gene VISTA enhancer hs1941 Neighboring gene secretin receptor Neighboring gene SCTR antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16452 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11907 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11908 Neighboring gene cilia and flagella associated protein 221 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11909 Neighboring gene MPRA-validated peak3833 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11910 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11911 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:120457784-120458983 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:120459450-120460055 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120460663-120461267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120472887-120473388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:120473389-120473888 Neighboring gene uncharacterized LOC101927764 Neighboring gene ribosomal protein L17 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11912 Neighboring gene Sharpr-MPRA regulatory region 5959 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:120517730-120518354 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16454 Neighboring gene protein tyrosine phosphatase non-receptor type 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11914 Neighboring gene MPRA-validated peak3834 silencer Neighboring gene small nucleolar RNA U13 Neighboring gene ribosomal protein L27 pseudogene 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The mitochondrial TMEM177 associates with COX20 during COX2 biogenesis. Lorenzi I, et al. Biochim Biophys Acta Mol Cell Res, 2018 Feb. PMID 29154948, Free PMC Article
    2. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Luo J, et al. Cell, 2009 May 29. PMID 19490893, Free PMC Article
    3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. Floyd BJ, et al. Mol Cell, 2016 Aug 18. PMID 27499296, Free PMC Article
    4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. Hillier LW, et al. Nature, 2005 Apr 7. PMID 15815621
    5. Unbiased Profiling of the Human Proinsulin Biosynthetic Interaction Network Reveals a Role for Peroxiredoxin 4 in Proinsulin Folding. Tran DT, et al. Diabetes, 2020 Aug. PMID 32457219, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ32751, MGC10993

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex II assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 

    General protein information

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    Preferred Names
    transmembrane protein 177

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105198.2 → NP_001098668.1  transmembrane protein 177

      See identical proteins and their annotated locations for NP_001098668.1

      Status: VALIDATED

      Source sequence(s)
      AC069154
      Consensus CDS
      CCDS2128.1
      UniProtKB/Swiss-Prot
      Q53S58, Q9BT20
      UniProtKB/TrEMBL
      B3KUD0
      Related
      ENSP00000402661.1, ENST00000424086.5
      Conserved Domains (1) summary
      cl02872
      Location:221 → 264
      DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

    2. NM_001105199.2 → NP_001098669.1  transmembrane protein 177

      See identical proteins and their annotated locations for NP_001098669.1

      Status: VALIDATED

      Source sequence(s)
      AC069154
      Consensus CDS
      CCDS2128.1
      UniProtKB/Swiss-Prot
      Q53S58, Q9BT20
      UniProtKB/TrEMBL
      B3KUD0
      Related
      ENSP00000385966.1, ENST00000401466.5
      Conserved Domains (1) summary
      cl02872
      Location:221 → 264
      DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

    3. NM_030577.3 → NP_085054.2  transmembrane protein 177

      See identical proteins and their annotated locations for NP_085054.2

      Status: VALIDATED

      Source sequence(s)
      AC069154
      Consensus CDS
      CCDS2128.1
      UniProtKB/Swiss-Prot
      Q53S58, Q9BT20
      UniProtKB/TrEMBL
      B3KUD0
      Related
      ENSP00000272521.6, ENST00000272521.7
      Conserved Domains (1) summary
      cl02872
      Location:221 → 264
      DHQ_Fe-ADH; Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH)

    RNA

    1. NR_148341.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC069154, AK057313, HY262393

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      119679201..119723618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_007082535.1 RNA Sequence

    2. XR_002959349.2 RNA Sequence

    3. XR_007082536.1 RNA Sequence

    4. XR_007082532.1 RNA Sequence

    5. XR_007082531.1 RNA Sequence

    6. XR_002959346.2 RNA Sequence

    7. XR_007082533.1 RNA Sequence

    8. XR_002959347.2 RNA Sequence

    9. XR_007082534.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      120112838..120157662
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008486537.1 RNA Sequence

    2. XR_008486538.1 RNA Sequence

    3. XR_008486536.1 RNA Sequence

    4. XR_008486539.1 RNA Sequence

    5. XR_008486531.1 RNA Sequence

    6. XR_008486530.1 RNA Sequence

    7. XR_008486533.1 RNA Sequence

    8. XR_008486532.1 RNA Sequence

    9. XR_008486534.1 RNA Sequence

    10. XR_008486535.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q53S58.1 GenPept UniProtKB/Swiss-Prot:Q53S58

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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