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    SLC22A7 solute carrier family 22 member 7 [ Homo sapiens (human) ]

    Gene ID: 10864, updated on 3-Dec-2024

    Summary

    Official Symbol
    SLC22A7provided by HGNC
    Official Full Name
    solute carrier family 22 member 7provided by HGNC
    Primary source
    HGNC:HGNC:10971
    See related
    Ensembl:ENSG00000137204 MIM:604995; AllianceGenome:HGNC:10971
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NLT; OAT2; hOAT11
    Summary
    The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in liver (RPKM 51.8) and kidney (RPKM 19.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC22A7 in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43295714..43305538)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43127200..43134478)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43265998..43273276)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17222 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43197001-43197500 Neighboring gene 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 Neighboring gene tau tubulin kinase 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43239819-43240068 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245015-43245670 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43245671-43246325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43254414-43255266 Neighboring gene Sharpr-MPRA regulatory region 10500 Neighboring gene uncharacterized LOC124901319 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43275224-43276081 Neighboring gene cysteine rich protein 3 Neighboring gene ribosomal protein L12 pseudogene 47 Neighboring gene ribosomal protein L34 pseudogene 14

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
    EBI GWAS Catalog

    Pathways from PubChem

    General gene information

    Markers

    Clone Names

    • MGC24091, MGC45202

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in alpha-ketoglutarate transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in organic anion transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in prostaglandin transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in xenobiotic metabolic process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basal plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    solute carrier family 22 member 7
    Names
    hOAT2
    liver-specific transporter
    novel liver transporter
    organic anion transporter 11
    organic anion transporter 2
    solute carrier family 22 (organic anion transporter), member 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006672.3NP_006663.2  solute carrier family 22 member 7 isoform a

      See identical proteins and their annotated locations for NP_006663.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a).
      Source sequence(s)
      AA705161, AF210455, BC033805, DA640137
      Consensus CDS
      CCDS4892.1
      UniProtKB/Swiss-Prot
      Q9Y694
      Related
      ENSP00000361670.3, ENST00000372589.7
      Conserved Domains (2) summary
      cd06174
      Location:126499
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11521
      2A0119; cation transport protein
    2. NM_153320.2NP_696961.2  solute carrier family 22 member 7 isoform b

      See identical proteins and their annotated locations for NP_696961.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate segment in the 5' coding region compared to variant 1. The encoded isoform (b) is longer compared to isoform a.
      Source sequence(s)
      AA705161, BC033805, DA640137
      Consensus CDS
      CCDS4893.2
      UniProtKB/Swiss-Prot
      B2CZX6, Q5T046, Q5T048, Q5T050, Q9H2W5, Q9Y694
      Related
      ENSP00000361666.5, ENST00000372585.10
      Conserved Domains (1) summary
      TIGR00898
      Location:11523
      2A0119; cation transport protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43295714..43305538
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418104.1XP_047274060.1  solute carrier family 22 member 7 isoform X10

      UniProtKB/TrEMBL
      A0A1Z4F6C0
    2. XM_017010199.3XP_016865688.1  solute carrier family 22 member 7 isoform X6

    3. XM_011514256.4XP_011512558.1  solute carrier family 22 member 7 isoform X1

      Conserved Domains (2) summary
      cd06174
      Location:206563
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11585
      2A0119; cation transport protein
    4. XM_017010198.3XP_016865687.1  solute carrier family 22 member 7 isoform X3

    5. XM_011514257.4XP_011512559.1  solute carrier family 22 member 7 isoform X2

      Conserved Domains (2) summary
      cd06174
      Location:206560
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11582
      2A0119; cation transport protein
    6. XM_047418103.1XP_047274059.1  solute carrier family 22 member 7 isoform X7

    7. XM_024446313.2XP_024302081.1  solute carrier family 22 member 7 isoform X5

      Conserved Domains (1) summary
      cl26863
      Location:11520
      Sugar_tr; Sugar (and other) transporter
    8. XM_047418102.1XP_047274058.1  solute carrier family 22 member 7 isoform X4

    9. XM_011514262.4XP_011512564.1  solute carrier family 22 member 7 isoform X8

      Conserved Domains (2) summary
      cd06174
      Location:206341
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      TIGR00898
      Location:11356
      2A0119; cation transport protein
    10. XM_047418105.1XP_047274061.1  solute carrier family 22 member 7 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      43127200..43134478
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354080.1XP_054210055.1  solute carrier family 22 member 7 isoform X6

    2. XM_054354075.1XP_054210050.1  solute carrier family 22 member 7 isoform X1

    3. XM_054354077.1XP_054210052.1  solute carrier family 22 member 7 isoform X3

    4. XM_054354076.1XP_054210051.1  solute carrier family 22 member 7 isoform X2

    5. XM_054354081.1XP_054210056.1  solute carrier family 22 member 7 isoform X7

    6. XM_054354079.1XP_054210054.1  solute carrier family 22 member 7 isoform X5

    7. XM_054354078.1XP_054210053.1  solute carrier family 22 member 7 isoform X4

    8. XM_054354082.1XP_054210057.1  solute carrier family 22 member 7 isoform X8

    9. XM_054354083.1XP_054210058.1  solute carrier family 22 member 7 isoform X9