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    MAPT-AS1 MAPT antisense RNA 1 [ Homo sapiens (human) ]

    Gene ID: 100128977, updated on 9-Dec-2024

    Summary

    Official Symbol
    MAPT-AS1provided by HGNC
    Official Full Name
    MAPT antisense RNA 1provided by HGNC
    Primary source
    HGNC:HGNC:43738
    See related
    AllianceGenome:HGNC:43738
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MAPT-AS
    Summary
    Involved in regulatory ncRNA-mediated gene silencing. Implicated in Parkinson's disease. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in brain (RPKM 1.4), testis (RPKM 0.7) and 2 other tissues See more
    NEW
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    Genomic context

    See MAPT-AS1 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45843356..45895513, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (46704980..46757136, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43920722..43972879, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene LINC02210-CRHR1 readthrough Neighboring gene uncharacterized LOC107985028 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43822876-43823542 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43823543-43824208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43828999-43829910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43835142-43835642 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43840160-43840660 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr17:43848965-43849573 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43862413-43862913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43869433-43869933 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43883739-43884240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43884241-43884740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43890849-43891705 Neighboring gene corticotropin releasing hormone receptor 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43900915-43901416 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:43917814-43918023 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43922169-43923153 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43923154-43924137 Neighboring gene signal peptide peptidase like 2C Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43971863-43972748 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43972749-43973634 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43974521-43975405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43983393-43983892 Neighboring gene MAPT intronic transcript 1 Neighboring gene uncharacterized LOC105371800 Neighboring gene microtubule associated protein tau

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
    EBI GWAS Catalog
    Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.
    EBI GWAS Catalog
    Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.
    EBI GWAS Catalog

    General gene information

    Markers

    Other Names

    • MAPT antisense RNA 1 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_024559.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AW205584, AW770488, BM714794

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      45843356..45895513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_167251.2 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      892701..944825
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187663.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      545477..597641 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      46704980..46757136 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)