Gigyf1 GRB10 interacting GYF protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gigyf1provided by MGI
Official Full Name: GRB10 interacting GYF protein 1provided by MGI
Primary source: MGI:MGI:1888677
See related: Ensembl:ENSMUSG00000029714 AllianceGenome:MGI:1888677
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Perq1; mKIAA4110
Summary: Acts upstream of or within insulin-like growth factor receptor signaling pathway. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Is expressed in several structures, including genitourinary system; liver; lung; nervous system; and spleen. Orthologous to human GIGYF1 (GRB10 interacting GYF protein 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression: Ubiquitous expression in thymus adult (RPKM 27.6), ovary adult (RPKM 21.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 76.53 cM

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137508470..137526197)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137510263..137527935)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
Title: Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice.
identification of proteins linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
Title: Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin-like growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within insulin-like growth factor receptor signaling pathway	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GRB10-interacting GYF protein 1

Names: GRB10 interacting GYF protein 2; PERQ amino acid rich, with GYF domain 1; PERQ amino acid-rich with GYF domain-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001403315.1 → NP_001390244.1 GRB10-interacting GYF protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC148018

UniProtKB/Swiss-Prot

Q571A0, Q6Y7W9, Q99MR1
NM_001403317.1 → NP_001390246.1 GRB10-interacting GYF protein 1 isoform b

Status: VALIDATED

Source sequence(s)

AC148018
NM_031408.3 → NP_113596.2 GRB10-interacting GYF protein 1 isoform a

Status: VALIDATED

Source sequence(s)

AC148018

Consensus CDS

CCDS51673.1

UniProtKB/Swiss-Prot

Q571A0, Q6Y7W9, Q99MR1

Related

ENSMUSP00000031727.8, ENSMUST00000031727.10

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:478 → 531

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000071.7 Reference GRCm39 C57BL/6J

Range

137508470..137526197

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165379.1 → XP_036021272.1 GRB10-interacting GYF protein 1 isoform X7

UniProtKB/Swiss-Prot

Q571A0, Q6Y7W9, Q99MR1

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:478 → 531

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_030254735.1 → XP_030110595.1 GRB10-interacting GYF protein 1 isoform X5

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:478 → 531

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006504609.4 → XP_006504672.1 GRB10-interacting GYF protein 1 isoform X3

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:506 → 559

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_011240952.3 → XP_011239254.1 GRB10-interacting GYF protein 1 isoform X2

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:506 → 559

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_011240953.3 → XP_011239255.1 GRB10-interacting GYF protein 1 isoform X4

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:506 → 559

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_036165380.1 → XP_036021273.1 GRB10-interacting GYF protein 1 isoform X8

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:478 → 531

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_011240950.3 → XP_011239252.1 GRB10-interacting GYF protein 1 isoform X1

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:506 → 559

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006504608.4 → XP_006504671.1 GRB10-interacting GYF protein 1 isoform X1

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:506 → 559

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_006504607.4 → XP_006504670.1 GRB10-interacting GYF protein 1 isoform X1

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:506 → 559

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
XM_030254736.2 → XP_030110596.1 GRB10-interacting GYF protein 1 isoform X6

Conserved Domains (2) summary

PRK12678
Location:113 → 265

PRK12678; transcription termination factor Rho; Provisional

cd00072
Location:477 → 530

GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.