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    Pim3 proviral integration site 3 [ Mus musculus (house mouse) ]

    Gene ID: 223775, updated on 4-Jan-2025

    Summary

    Official Symbol
    Pim3provided by MGI
    Official Full Name
    proviral integration site 3provided by MGI
    Primary source
    MGI:MGI:1355297
    See related
    Ensembl:ENSMUSG00000035828 AllianceGenome:MGI:1355297
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kid1
    Summary
    Predicted to enable protein serine/threonine kinase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including epithelium; exocrine gland; genitourinary system; hemolymphoid system gland; and nervous system. Orthologous to human PIM3 (Pim-3 proto-oncogene, serine/threonine kinase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Broad expression in adrenal adult (RPKM 73.4), duodenum adult (RPKM 37.2) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Pim3 in Genome Data Viewer
    Location:
    15 E3; 15 44.36 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (88746397..88749929)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (88862194..88865726)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene predicted gene, 23144 Neighboring gene STARR-positive B cell enhancer ABC_E4145 Neighboring gene CapStarr-seq enhancer MGSCv37_chr15:88692779-88692962 Neighboring gene predicted gene, 33049 Neighboring gene STARR-seq mESC enhancer starr_39448 Neighboring gene predicted gene, 38643 Neighboring gene tubulin tyrosine ligase-like family, member 8 Neighboring gene STARR-seq mESC enhancer starr_39454 Neighboring gene megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC27707, MGC37517

    Gene Ontology Provided by MGI

    Items 1 - 25 of 26
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding  
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables protein binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    Items 1 - 25 of 26
    Process Evidence Code Pubs
    involved_in apoptotic process  
    involved_in chromatin remodeling  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in protein phosphorylation  
    involved_in protein phosphorylation  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    involved_in regulation of mitotic cell cycle  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    serine/threonine-protein kinase pim-3
    Names
    KID-1/kinase induced by depolarization
    NP_663453.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145478.2NP_663453.1  serine/threonine-protein kinase pim-3

      See identical proteins and their annotated locations for NP_663453.1

      Status: PROVISIONAL

      Source sequence(s)
      AC117700
      Consensus CDS
      CCDS27734.1
      UniProtKB/Swiss-Prot
      P58750
      UniProtKB/TrEMBL
      Q3TX64, Q811X8
      Related
      ENSMUSP00000044603.10, ENSMUST00000042818.11
      Conserved Domains (1) summary
      cl21453
      Location:39293
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      88746397..88749929
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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