Rnf25 ring finger protein 25 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf25provided by MGI
Official Full Name: ring finger protein 25provided by MGI
Primary source: MGI:MGI:1890215
See related: Ensembl:ENSMUSG00000026171 AllianceGenome:MGI:1890215
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AO7; 0610009H16Rik
Summary: Enables ubiquitin protein ligase activity. Involved in protein ubiquitination. Predicted to be located in cytosol. Predicted to be active in cytosolic ribosome and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human RNF25 (ring finger protein 25). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in testis adult (RPKM 37.6), limb E14.5 (RPKM 24.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 C4; 1 38.54 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (74632907..74640556, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (74593748..74601397, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify an EGFR-independent action of TGF-alpha, in which it protects Naked2 from proteasomal degradation, thus ensuring its delivery to the basolateral surface of polarized epithelial cells
Title: EGF receptor-independent action of TGF-alpha protects Naked2 from AO7-mediated ubiquitylation and proteasomal degradation.
RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.
Title: RING finger protein AO7 supports NF-kappaB-mediated transcription by interacting with the transactivation domain of the p65 subunit.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

MARC_21861-21862:1027094738:1 (e-PCR)
- UniSTS:268654

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NF-kappaB binding	ISO Inferred from Sequence Orthology more info
enables NF-kappaB binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein K6-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein K6-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-RNA covalent cross-linking repair	IEA Inferred from Electronic Annotation more info
involved_in protein-RNA covalent cross-linking repair	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in rescue of stalled ribosome	ISO Inferred from Sequence Orthology more info
involved_in rescue of stalled ribosome	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosolic ribosome	IEA Inferred from Electronic Annotation more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF25

Names: RING finger protein AO7; RING-type E3 ubiquitin transferase RNF25

NP_001292159.1

EC 2.3.2.27

NP_067288.2

EC 2.3.2.27

XP_006496233.1

EC 2.3.2.27

XP_030111555.1

EC 2.3.2.27

XP_036008396.1

EC 2.3.2.27

XP_036008397.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001305230.1 → NP_001292159.1 E3 ubiquitin-protein ligase RNF25 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant (1). The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC117610, AK002399, AK011171, BG081026, BP774070

Consensus CDS

CCDS78620.1

UniProtKB/TrEMBL

E9Q446

Related

ENSMUSP00000109350.2, ENSMUST00000113721.8

Conserved Domains (2) summary

smart00591
Location:19 → 127

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam13639
Location:132 → 198

zf-RING_2; Ring finger domain
NM_021313.3 → NP_067288.2 E3 ubiquitin-protein ligase RNF25 isoform 1

See identical proteins and their annotated locations for NP_067288.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC117610, AK002399, BE853767, BP774070

Consensus CDS

CCDS15052.1

UniProtKB/Swiss-Prot

Q3TAL8, Q9DCW7, Q9QZR0

Related

ENSMUSP00000027357.6, ENSMUST00000027357.12

Conserved Domains (2) summary

smart00591
Location:19 → 127

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

pfam13639
Location:132 → 199

zf-RING_2; Ring finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

74632907..74640556 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152504.1 → XP_036008397.1 E3 ubiquitin-protein ligase RNF25 isoform X4

Conserved Domains (1) summary

cd16470
Location:22 → 88

RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
XM_036152503.1 → XP_036008396.1 E3 ubiquitin-protein ligase RNF25 isoform X3

Conserved Domains (1) summary

cd16470
Location:22 → 89

RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
XM_030255695.2 → XP_030111555.1 E3 ubiquitin-protein ligase RNF25 isoform X2

Conserved Domains (2) summary

smart00591
Location:6 → 94

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

cd16470
Location:100 → 166

RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
XM_006496170.3 → XP_006496233.1 E3 ubiquitin-protein ligase RNF25 isoform X1

Conserved Domains (2) summary

smart00591
Location:6 → 94

RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain

cd16470
Location:100 → 167

RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins