Arfgap3 ARF GTPase activating protein 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arfgap3provided by MGI
Official Full Name: ARF GTPase activating protein 3provided by MGI
Primary source: MGI:MGI:1913501
See related: Ensembl:ENSMUSG00000054277 AllianceGenome:MGI:1913501
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Arfgap1; 0610009H19Rik; 1810004P07Rik; 1810035F16Rik; 9130416J18Rik
Summary: Predicted to enable GTPase activator activity. Involved in presynaptic endocytosis. Is active in photoreceptor ribbon synapse and presynaptic active zone. Orthologous to human ARFGAP3 (ADP ribosylation factor GTPase activating protein 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 30.0), colon adult (RPKM 25.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 39.4 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (83183940..83234576, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (83299739..83350375, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effects of mechanical trauma on the differentiation and ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle.
Title: Effects of mechanical trauma on the differentiation and ArfGAP3 expression of C2C12 myoblast and mouse levator ani muscle.
ArfGAP3 interacts with RIBEYE in an NAD(H)-dependent manner.
Title: ArfGAP3 is a component of the photoreceptor synaptic ribbon complex and forms an NAD(H)-regulated, redox-sensitive complex with RIBEYE that is important for endocytosis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activator activity	ISO Inferred from Sequence Orthology more info
enables GTPase activator activity	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in COPI coating of Golgi vesicle	IBA Inferred from Biological aspect of Ancestor more info
involved_in presynaptic endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in photoreceptor ribbon synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ADP-ribosylation factor GTPase-activating protein 3

Names: ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase activating protein 3; ARF GAP 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001357756.1 → NP_001344685.1 ADP-ribosylation factor GTPase-activating protein 3 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC165945

Conserved Domains (2) summary

smart00105
Location:13 → 116

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

pfam09507
Location:134 → 292

CDC27; DNA polymerase subunit Cdc27
NM_001357757.1 → NP_001344686.1 ADP-ribosylation factor GTPase-activating protein 3 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.

Source sequence(s)

AC165945

Consensus CDS

CCDS88818.1

UniProtKB/Swiss-Prot

Q544V6, Q8BW06, Q99KN8, Q9D8S3

Related

ENSMUSP00000154712.2, ENSMUST00000226124.2

Conserved Domains (2) summary

smart00105
Location:13 → 116

ArfGap; Putative GTP-ase activating proteins for the small GTPase, ARF

pfam09507
Location:134 → 291

CDC27; DNA polymerase subunit Cdc27
NM_025445.4 → NP_079721.2 ADP-ribosylation factor GTPase-activating protein 3 isoform 3

See identical proteins and their annotated locations for NP_079721.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.

Source sequence(s)

AC165945

Consensus CDS

CCDS49683.1

UniProtKB/TrEMBL

A0A0R4J0T8

Related

ENSMUSP00000064893.8, ENSMUST00000067215.9

Conserved Domains (2) summary

PLN03114
Location:1 → 241

PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional

pfam01412
Location:11 → 121

ArfGap; Putative GTPase activating protein for Arf

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

83183940..83234576 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521254.4 → XP_006521317.2 ADP-ribosylation factor GTPase-activating protein 3 isoform X1

Conserved Domains (2) summary

PLN03114
Location:1 → 242

PLN03114; ADP-ribosylation factor GTPase-activating protein AGD10; Provisional

cd09028
Location:4 → 123

ArfGap_ArfGap3; Arf1 GTPase-activating protein 3