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    Nexmif neurite extension and migration factor [ Mus musculus (house mouse) ]

    Gene ID: 245555, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nexmifprovided by MGI
    Official Full Name
    neurite extension and migration factorprovided by MGI
    Primary source
    MGI:MGI:2148050
    See related
    Ensembl:ENSMUSG00000046449 AllianceGenome:MGI:2148050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Xpn; KIDLIA; A230051P11
    Summary
    Predicted to be involved in negative regulation of cell adhesion and negative regulation of neuron migration. Predicted to be located in cytosol; midbody; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including brain; neural tube mantle layer; sensory organ; skeleton; and tarsus. Used to study autism spectrum disorder and non-syndromic X-linked intellectual disability 98. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 98. Orthologous to human NEXMIF (neurite extension and migration factor). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E18 (RPKM 4.6), whole brain E14.5 (RPKM 2.8) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nexmif in Genome Data Viewer
    Location:
    X D; X 46.48 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (103120367..103245403, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (104076761..104201783, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_47704 Neighboring gene predicted gene, 23378 Neighboring gene predicted gene, 22266 Neighboring gene microRNA 672 Neighboring gene STARR-seq mESC enhancer starr_47705 Neighboring gene STARR-seq mESC enhancer starr_47706 Neighboring gene STARR-seq mESC enhancer starr_47707 Neighboring gene STARR-seq mESC enhancer starr_47708 Neighboring gene STARR-seq mESC enhancer starr_47709 Neighboring gene ATP-binding cassette, sub-family B member 7 Neighboring gene valosin containing protein, related sequence Neighboring gene 39S ribosomal protein L30, mitochondrial pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The autism spectrum disorder risk gene NEXMIF over-synchronizes hippocampal CA1 network and alters neuronal coding. Mount RA, et al. Front Neurosci, 2023. PMID 37965217, Free PMC Article
    2. Loss of Nexmif results in the expression of phenotypic variability and loss of genomic integrity. Stekelenburg C, et al. Sci Rep, 2022 Aug 15. PMID 35970867, Free PMC Article
    3. NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function. Gilbert J, et al. J Neurosci, 2020 Jan 2. PMID 31704787, Free PMC Article
    4. Transient expression of Xpn, an XLMR protein related to neurite extension, during brain development and participation in neurite outgrowth. Ishikawa T, et al. Neuroscience, 2012 Jul 12. PMID 22531377
    5. XLMR protein related to neurite extension (Xpn/KIAA2022) regulates cell-cell and cell-matrix adhesion and migration. Magome T, et al. Neurochem Int, 2013 Nov. PMID 24071057

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ale NEXMIF KO mice demonstrate reduced sociability and communication, elevated repetitive grooming behavior, and deficits in learning and memory. Loss of NEXMIF/KIDLIA expression results in a significant decrease in synapse density and synaptic protein expression. Male KO animals show aberrant synaptic function as measured by excitatory miniatures and postsynaptic currents in the hippocampus.
      Title: NEXMIF/KIDLIA Knock-out Mouse Demonstrates Autism-Like Behaviors, Memory Deficits, and Impairments in Synapse Formation and Function.
    2. Knockdown of KIAA2022/KIDLIA leads to altered neuron migration and a reduction in dendritic growth and disorganized apical dendrite projections in layer II/III cortical neurons. In cultured neurons loss of KIDLIA expression also leads to suppression of dendritic growth and branching. KIDLIA suppression leads to an increase in cell-surface N-cadherin and an elevated association of N-cadherin with delta-catenin.
      Title: The X-Linked Autism Protein KIAA2022/KIDLIA Regulates Neurite Outgrowth via N-Cadherin and δ-Catenin Signaling.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4)  1 citation
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA2022

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in negative regulation of cell adhesion mediated by integrin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell adhesion mediated by integrin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell adhesion mediated by integrin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell-matrix adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell-matrix adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuron migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of neuron migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuron migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    neurite extension and migration factor
    Names
    XLMR protein related to neurite extension

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077354.3 → NP_001070822.2  neurite extension and migration factor

      See identical proteins and their annotated locations for NP_001070822.2

      Status: VALIDATED

      Source sequence(s)
      AL671963
      Consensus CDS
      CCDS53166.1
      UniProtKB/Swiss-Prot
      Q003Y8, Q5DTT1, Q8BW26, Q8BYR0
      UniProtKB/TrEMBL
      Q003Y7
      Related
      ENSMUSP00000085187.5, ENSMUST00000087879.11
      Conserved Domains (1) summary
      pfam15735
      Location:284 → 690
      DUF4683; Domain of unknown function (DUF4683)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      103120367..103245403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251340.2 → XP_030107200.1  neurite extension and migration factor isoform X1

      UniProtKB/Swiss-Prot
      Q003Y8, Q5DTT1, Q8BW26, Q8BYR0
      UniProtKB/TrEMBL
      Q003Y7
      Conserved Domains (1) summary
      pfam15735
      Location:284 → 690
      DUF4683; Domain of unknown function (DUF4683)

    2. XM_006528031.5 → XP_006528094.1  neurite extension and migration factor isoform X1

      See identical proteins and their annotated locations for XP_006528094.1

      UniProtKB/Swiss-Prot
      Q003Y8, Q5DTT1, Q8BW26, Q8BYR0
      UniProtKB/TrEMBL
      Q003Y7
      Conserved Domains (1) summary
      pfam15735
      Location:284 → 690
      DUF4683; Domain of unknown function (DUF4683)

    3. XM_030251339.2 → XP_030107199.1  neurite extension and migration factor isoform X1

      UniProtKB/Swiss-Prot
      Q003Y8, Q5DTT1, Q8BW26, Q8BYR0
      UniProtKB/TrEMBL
      Q003Y7
      Conserved Domains (1) summary
      pfam15735
      Location:284 → 690
      DUF4683; Domain of unknown function (DUF4683)

    4. XM_006528034.5 → XP_006528097.1  neurite extension and migration factor isoform X1

      See identical proteins and their annotated locations for XP_006528097.1

      UniProtKB/Swiss-Prot
      Q003Y8, Q5DTT1, Q8BW26, Q8BYR0
      UniProtKB/TrEMBL
      Q003Y7
      Conserved Domains (1) summary
      pfam15735
      Location:284 → 690
      DUF4683; Domain of unknown function (DUF4683)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5DTT1.3 GenPept UniProtKB/Swiss-Prot:Q5DTT1

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