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    BACE2 beta-secretase 2 [ Gallus gallus (chicken) ]

    Gene ID: 418526, updated on 3-Dec-2024

    Summary

    Official Symbol
    BACE2provided by CGNC
    Official Full Name
    beta-secretase 2provided by CGNC
    Primary source
    CGNC:12064
    See related
    Ensembl:ENSGALG00010013650
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
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    Genomic context

    See BACE2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (108914679..108971445)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (109004057..109060915)

    Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121107532 Neighboring gene DS cell adhesion molecule Neighboring gene uncharacterized LOC121107534 Neighboring gene uncharacterized LOC121107536 Neighboring gene family with sequence similarity 3 member B Neighboring gene MX dynamin like GTPase 1

    Genomic regions, transcripts, and products

    General gene information

    Markers

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables aspartic-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in amyloid-beta metabolic process IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    involved_in membrane protein ectodomain proteolysis IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    PubMed 
    located_in trans-Golgi network IEA
    Inferred from Electronic Annotation
    more info
    PubMed 

    General protein information

    Preferred Names
    beta-secretase 2
    Names
    beta-site APP-cleaving enzyme 2
    XP_015156677.2
    XP_040508181.1
    XP_040515610.1
    XP_046765663.1
    XP_046765664.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      108914679..108971445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015301191.4XP_015156677.2  beta-secretase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YF22
      Related
      ENSGALP00010019433.1, ENSGALT00010032810.1
      Conserved Domains (1) summary
      cd05473
      Location:89450
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    2. XM_040652247.2XP_040508181.1  beta-secretase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF22
      Conserved Domains (1) summary
      cd05473
      Location:16364
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      109004057..109060915
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040659676.2XP_040515610.1  beta-secretase 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YF22
      Conserved Domains (1) summary
      cd05473
      Location:89450
      beta_secretase_like; Beta-secretase, aspartic-acid protease important in the pathogenesis of Alzheimer's disease
    2. XM_046909708.1XP_046765664.1  beta-secretase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF22
    3. XM_046909707.1XP_046765663.1  beta-secretase 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YF22