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    DRP2 dystrophin related protein 2 [ Gallus gallus (chicken) ]

    Gene ID: 422193, updated on 17-Aug-2024

    Summary

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    Symbol
    DRP2provided by CGNC
    Full Name
    dystrophin related protein 2provided by CGNC
    Primary source
    CGNC:3740
    See related
    Ensembl:ENSGALG00010016053
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See DRP2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 4 NC_052535.1 (2012111..2030413, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 4 NC_052576.1 (2048632..2066896, complement)

    Chromosome 4 - NC_052535.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110550 Neighboring gene TATA-box binding protein associated factor 7 Neighboring gene aryl hydrocarbon receptor interacting protein like 1 Neighboring gene centromere protein I Neighboring gene transmembrane protein 35A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in synaptic signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    dystrophin-related protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      2012111..2030413 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040700020.2 → XP_040555954.1  dystrophin-related protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:33 → 261
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:279 → 307
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:530 → 578
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:344 → 505
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    2. XM_025150290.3 → XP_025006058.1  dystrophin-related protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    3. XM_015278392.4 → XP_015133878.1  dystrophin-related protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    4. XM_015278393.4 → XP_015133879.1  dystrophin-related protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YN00, A0A8V0YN05
      Related
      ENSGALP00010022361.1, ENSGALT00010038647.1
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    5. XM_040700012.2 → XP_040555946.1  dystrophin-related protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN00
      Related
      ENSGALP00010022356.1, ENSGALT00010038639.1
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    6. XM_015278394.3 → XP_015133880.1  dystrophin-related protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:33 → 261
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:279 → 307
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:530 → 578
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:344 → 505
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      2048632..2066896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040669500.2 → XP_040525434.1  dystrophin-related protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:33 → 261
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:279 → 307
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:530 → 578
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:344 → 505
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    2. XM_040669499.2 → XP_040525433.1  dystrophin-related protein 2 isoform X4

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    3. XM_040669497.2 → XP_040525431.1  dystrophin-related protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    4. XM_040669498.2 → XP_040525432.1  dystrophin-related protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8V0YN00, A0A8V0YN05
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    5. XM_040669490.2 → XP_040525424.1  dystrophin-related protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:98 → 326
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:344 → 372
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:595 → 643
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:409 → 570
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)

    6. XM_040669501.1 → XP_040525435.1  dystrophin-related protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8V0YN00
      Conserved Domains (4) summary
      cd00176
      Location:33 → 261
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd00201
      Location:279 → 307
      WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
      cd02334
      Location:530 → 578
      ZZ_dystrophin; Zinc finger, ZZ type. Zinc finger present in dystrophin and dystrobrevin. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Dystrophin attaches actin filaments to an integral membrane ...
      cd16248
      Location:344 → 505
      EFh_DRP-2; EF-hand-like motif found in dystrophin-related protein 2 (DRP-2)
    Nucleotide Protein Strain
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