Rps3a1 ribosomal protein S3A1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rps3a1provided by MGI
Official Full Name: ribosomal protein S3A1provided by MGI
Primary source: MGI:MGI:1202063
See related: Ensembl:ENSMUSG00000028081 AllianceGenome:MGI:1202063
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rps3a
Summary: A structural constituent of ribosome. Predicted to be involved in negative regulation of apoptotic process; ribosomal small subunit biogenesis; and translation. Located in cytosol and nucleus. Part of cytosolic small ribosomal subunit. Is active in synapse. Is expressed in embryo and tail. Orthologous to human RPS3A (ribosomal protein S3A). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in CNS E11.5 (RPKM 670.7), bladder adult (RPKM 656.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F1; 3 37.83 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (86045247..86049975, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (86137940..86142668, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This dysregulation is also seen in AdarDelta2-13; Mavs-/- but not in AdarE861A/E861A; Ifih1-/- mice, suggesting editing-independent functions of ADAR in regulating expression levels of Rps3a1 and Rps3a3.
Title: An internal deletion of ADAR rescued by MAVS deficiency leads to a minute phenotype.
RPS3a as an essential component for LPS-mediated pro-inflammatory signaling
Title: Esculentoside A specifically binds to ribosomal protein S3a and impairs LPS-induced signaling in macrophages.
The mouse ribosomal and chaperone protein RPS3A was identified as a suppressor of alphaSyn [WT (wild-type) and A53T] toxicity in yeast
Title: Mammalian ribosomal and chaperone protein RPS3A counteracts α-synuclein aggregation and toxicity in a yeast model system.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125547 (e-PCR)
- UniSTS:162361

D4S2325 (e-PCR)
- UniSTS:33148

RH125422 (e-PCR)
- UniSTS:162244

GDB:554881 (e-PCR)
- UniSTS:157662

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mRNA 5'-UTR binding	ISO Inferred from Sequence Orthology more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables translation initiation factor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	ISO Inferred from Sequence Orthology more info
involved_in translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
part_of ribonucleoprotein complex	ISO Inferred from Sequence Orthology more info	PubMed
part_of ribonucleoprotein complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
part_of small ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: small ribosomal subunit protein eS1

Names: 40S ribosomal protein S3a; ribosomal protein S3A

NP_058655.3

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.