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    Arl14ep ADP-ribosylation factor-like 14 effector protein [ Mus musculus (house mouse) ]

    Gene ID: 212772, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Arl14epprovided by MGI
    Official Full Name
    ADP-ribosylation factor-like 14 effector proteinprovided by MGI
    Primary source
    MGI:MGI:1926020
    See related
    Ensembl:ENSMUSG00000027122 AllianceGenome:MGI:1926020
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ARF7EP; 2700007P21Rik; 4930448O08Rik
    Summary
    Predicted to be located in several cellular components, including cytosol; focal adhesion; and nuclear lumen. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in cerebral cortex ventricular layer; olfactory cortex ventricular layer; olfactory epithelium; and telencephalon ventricular layer. Orthologous to human ARL14EP (ARF like GTPase 14 effector protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.0), limb E14.5 (RPKM 6.9) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Arl14ep in Genome Data Viewer
    Location:
    2 E3; 2 55.97 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (106792874..106804742, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (106962529..106974397, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 54139 Neighboring gene high mobility group box 2 pseudogene Neighboring gene predicted gene, 39902 Neighboring gene STARR-seq mESC enhancer starr_05332 Neighboring gene STARR-seq mESC enhancer starr_05333 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene follicle stimulating hormone beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The level of the transcription factor Pax6 is essential for controlling the balance between neural stem cell self-renewal and neurogenesis. Sansom SN, et al. PLoS Genet, 2009 Jun. PMID 19521500, Free PMC Article
    2. Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation. Barnes CE, et al. Mol Omics, 2022 Jan 17. PMID 34709266, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    ARL14 effector protein
    Names
    ARF7 effector protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025102.2 → NP_001020273.1  ARL14 effector protein

      See identical proteins and their annotated locations for NP_001020273.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      BX649348, BX890640
      Consensus CDS
      CCDS16503.1
      UniProtKB/Swiss-Prot
      Q7TPE6, Q8BIX3, Q9CZS0
      Related
      ENSMUSP00000028536.7, ENSMUST00000028536.13
      Conserved Domains (1) summary
      pfam14949
      Location:145 → 248
      ARF7EP_C; ARF7 effector protein C-terminus

    2. NM_001362864.1 → NP_001349793.1  ARL14 effector protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      BX649348, BX890640
      Consensus CDS
      CCDS16503.1
      UniProtKB/Swiss-Prot
      Q7TPE6, Q8BIX3, Q9CZS0
      Conserved Domains (1) summary
      pfam14949
      Location:145 → 248
      ARF7EP_C; ARF7 effector protein C-terminus

    3. NM_001362865.1 → NP_001349794.1  ARL14 effector protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      BX649348, BX890640
      Consensus CDS
      CCDS16503.1
      UniProtKB/Swiss-Prot
      Q7TPE6, Q8BIX3, Q9CZS0
      Conserved Domains (1) summary
      pfam14949
      Location:145 → 248
      ARF7EP_C; ARF7 effector protein C-terminus

    4. NM_173750.2 → NP_776111.1  ARL14 effector protein

      See identical proteins and their annotated locations for NP_776111.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. All four variants encode the same protein.
      Source sequence(s)
      AA407700, AI552408, AK076781, BB595211, BE648222, BY651964, CA327681, CK623335
      Consensus CDS
      CCDS16503.1
      UniProtKB/Swiss-Prot
      Q7TPE6, Q8BIX3, Q9CZS0
      Related
      ENSMUSP00000091409.4, ENSMUST00000093883.4
      Conserved Domains (1) summary
      pfam14949
      Location:145 → 248
      ARF7EP_C; ARF7 effector protein C-terminus

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      106792874..106804742 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIX3.1 GenPept UniProtKB/Swiss-Prot:Q8BIX3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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