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    Rbms2 RNA binding motif, single stranded interacting protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 56516, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Rbms2provided by MGI
    Official Full Name
    RNA binding motif, single stranded interacting protein 2provided by MGI
    Primary source
    MGI:MGI:1861776
    See related
    Ensembl:ENSMUSG00000040043 AllianceGenome:MGI:1861776
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Scr3; 2610315E04Rik
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Is expressed in central nervous system; genitourinary system; and sensory organ. Orthologous to human RBMS2 (RNA binding motif single stranded interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 29.7), mammary gland adult (RPKM 26.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rbms2 in Genome Data Viewer
    Location:
    10 D3; 10 76.41 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127965339..128016166, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128129470..128180297, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E8377 Neighboring gene ATP synthase F1 subunit beta Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127529132-127529333 Neighboring gene STARR-positive B cell enhancer ABC_E8993 Neighboring gene STARR-seq mESC enhancer starr_28259 Neighboring gene microRNA 677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127534859-127535012 Neighboring gene STARR-seq mESC enhancer starr_28261 Neighboring gene bromodomain adjacent to zinc finger domain, 2A Neighboring gene predicted gene, 51821 Neighboring gene STARR-positive B cell enhancer ABC_E11466 Neighboring gene STARR-seq mESC enhancer starr_28269 Neighboring gene STARR-positive B cell enhancer ABC_E11760 Neighboring gene predicted gene 4556 Neighboring gene glutaminase 2 (liver, mitochondrial) Neighboring gene SPRY domain containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Effects of SCR-3 on the immunosuppression accompanied with the systemic inflammatory response syndrome. Li J, et al. Mol Cell Biochem, 2012 May. PMID 22198336
    2. Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein. Fujimoto M, et al. Int J Oncol, 2000 Feb. PMID 10639566
    3. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article
    4. Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair. Srivastava A, et al. J Biosci, 2020. PMID 32098917
    5. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif, single-stranded-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001039080.2 → NP_001034169.1  RNA-binding motif, single-stranded-interacting protein 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a different 5' UTR and a downstream AUG start codon, compared to variant 1. The resulting isoform (b) has a shorter N-terminus, compared to isoform a. Variants 2 and 5 both encode the same isoform (b).
      Source sequence(s)
      AC135859, AC166817
      Consensus CDS
      CCDS24262.1
      UniProtKB/TrEMBL
      E9Q7G6, Q3UGN4
      Related
      ENSMUSP00000096742.2, ENSMUST00000099139.9
      Conserved Domains (2) summary
      cd12471
      Location:25 → 108
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cd12474
      Location:109 → 194
      RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

    2. NM_001429220.1 → NP_001416149.1  RNA-binding motif, single-stranded-interacting protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC135859, AC166817
      UniProtKB/Swiss-Prot
      Q8VC70

    3. NM_001429221.1 → NP_001416150.1  RNA-binding motif, single-stranded-interacting protein 2 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC135859, AC166817
      UniProtKB/Swiss-Prot
      Q8VC70

    4. NM_001429222.1 → NP_001416151.1  RNA-binding motif, single-stranded-interacting protein 2 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC135859, AC166817
      UniProtKB/TrEMBL
      E9Q7G6

    5. NM_001429223.1 → NP_001416152.1  RNA-binding motif, single-stranded-interacting protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC135859, AC166817

    6. NM_019711.3 → NP_062685.2  RNA-binding motif, single-stranded-interacting protein 2 isoform a

      See identical proteins and their annotated locations for NP_062685.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1, 3, and 4 all encode the same isoform (a).
      Source sequence(s)
      AC135859, AC166817
      Consensus CDS
      CCDS24261.1
      UniProtKB/Swiss-Prot
      Q8VC70
      UniProtKB/TrEMBL
      Q3UGN4
      Related
      ENSMUSP00000089664.3, ENSMUST00000092033.4
      Conserved Domains (2) summary
      cd12474
      Location:137 → 222
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:53 → 136
      RRM_SF; RNA recognition motif (RRM) superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127965339..128016166 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513900.3 → XP_006513963.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

      Conserved Domains (2) summary
      cd12474
      Location:137 → 222
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:53 → 136
      RRM_SF; RNA recognition motif (RRM) superfamily

    2. XM_036155899.1 → XP_036011792.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

      Conserved Domains (2) summary
      cd12471
      Location:25 → 108
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cd12474
      Location:109 → 194
      RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

    3. XM_006513899.2 → XP_006513962.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

      Conserved Domains (2) summary
      cd12474
      Location:137 → 222
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:53 → 136
      RRM_SF; RNA recognition motif (RRM) superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VC70.1 GenPept UniProtKB/Swiss-Prot:Q8VC70

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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