Poldip2 polymerase (DNA-directed), delta interacting protein 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Poldip2provided by MGI
Official Full Name: polymerase (DNA-directed), delta interacting protein 2provided by MGI
Primary source: MGI:MGI:1915061
See related: Ensembl:ENSMUSG00000001100 AllianceGenome:MGI:1915061
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pdip38; 1300003F06Rik
Summary: Predicted to enable protein-macromolecule adaptor activity. Acts upstream of or within mitochondrion organization; negative regulation of macroautophagy; and positive regulation of mitotic cell cycle. Located in mitochondrion. Is expressed in genitourinary system. Orthologous to human POLDIP2 (DNA polymerase delta interacting protein 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in testis adult (RPKM 47.2), adrenal adult (RPKM 46.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.74 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (78403105..78413562)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (78512296..78522736)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation.
Title: Endothelial Poldip2 regulates sepsis-induced lung injury via Rho pathway activation.
Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome.
Title: Myeloid Poldip2 Contributes to the Development of Pulmonary Inflammation by Regulating Neutrophil Adhesion in a Murine Model of Acute Respiratory Distress Syndrome.
Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting.
Title: Characterization of Poldip2 knockout mice: Avoiding incorrect gene targeting.
Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction.
Title: Poldip2 controls leukocyte infiltration into the ischemic brain by regulating focal adhesion kinase-mediated VCAM-1 induction.
Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
Title: Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model.
Preservation of the differentiated phenotype in Poldip2+/- mice inhibits neointima formation after injury. Poldip2 deficiency induces a highly differentiated phenotype in VSMCs through a mechanism that involves regulation of metabolism and proteostasis.
Title: Mitochondrial Protein Poldip2 (Polymerase Delta Interacting Protein 2) Controls Vascular Smooth Muscle Differentiated Phenotype by O-Linked GlcNAc (N-Acetylglucosamine) Transferase-Dependent Inhibition of a Ubiquitin Proteasome System.
These data suggest Poldip2 mediates LPS-induced blood-brain barrier disruption by regulating NF-kappaBeta subunit p65 activation and Cox-2 and prostaglandin E2 induction.
Title: Poldip2 mediates blood-brain barrier disruption in a model of sepsis-associated encephalopathy.
hepatic dysregulation of Poldip2 may contribute to diabetic dyslipidemia and hyperglycemia
Title: Hepatic deficiency of Poldip2 in type 2 diabetes dampens lipid and glucose homeostasis.
Heterozygous deletion of Poldip2 protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.
Title: Poldip2 deficiency protects against lung edema and vascular inflammation in a model of acute respiratory distress syndrome.
Polidip2 is up-regulated following cerebral ischemia and mediates the breakdown of the blood-brain barrier.
Title: Polymerase delta-interacting protein 2 deficiency protects against blood-brain barrier permeability in the ischemic brain.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Gene trapped (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236655

RH136114 (e-PCR)
- UniSTS:210109

D11Seg33 (e-PCR), detects polymorphism
- UniSTS:141808

D11Seg38 (e-PCR), detects polymorphism
- UniSTS:141813

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
involved_in error-free translesion synthesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in error-free translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in error-free translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mitochondrion organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle assembly	IEA Inferred from Electronic Annotation more info
involved_in mitotic spindle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of macroautophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of focal adhesion assembly	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cytokinesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in vascular associated smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in vascular associated smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISS Inferred from Sequence or Structural Similarity more info
is_active_in mitochondrial nucleoid	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial nucleoid	IEA Inferred from Electronic Annotation more info
located_in mitochondrial nucleoid	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polymerase delta-interacting protein 2

Names: mitogenin 1; mitogenin I; polymerase delta interacting protein 38

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_026389.4 → NP_080665.1 polymerase delta-interacting protein 2 precursor

See identical proteins and their annotated locations for NP_080665.1

Status: VALIDATED

Source sequence(s)

AL591177

Consensus CDS

CCDS25109.1

UniProtKB/Swiss-Prot

Q91VA6

Related

ENSMUSP00000001127.5, ENSMUST00000001127.11

Conserved Domains (2) summary

cl01119
Location:234 → 355

DUF525; Protein of unknown function (DUF525)

cl01548
Location:74 → 200

YccV-like; Hemimethylated DNA-binding protein YccV like