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    Adamts4 ADAM metallopeptidase with thrombospondin type 1 motif 4 [ Mus musculus (house mouse) ]

    Gene ID: 240913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Adamts4provided by MGI
    Official Full Name
    ADAM metallopeptidase with thrombospondin type 1 motif 4provided by MGI
    Primary source
    MGI:MGI:1339949
    See related
    Ensembl:ENSMUSG00000006403 AllianceGenome:MGI:1339949
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ADMP-1; ADAM-TS4; ADAMTS-2
    Summary
    This gene encodes a member of "a disintegrin and metalloproteinase with thrombospondin motifs" (ADAMTS) family of multi-domain matrix-associated metalloendopeptidases that have diverse roles in tissue morphogenesis and pathophysiological remodeling, in inflammation and in vascular biology. The encoded preproprotein undergoes proteolytic processing to generate an active zinc-dependent aggrecanase enzyme that degrades cartilage. [provided by RefSeq, Jul 2016]
    Expression
    Broad expression in ovary adult (RPKM 13.3), cerebellum adult (RPKM 7.1) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Adamts4 in Genome Data Viewer
    Location:
    1 H3; 1 79.28 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171077698..171089836)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171250129..171262267)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene translocase of outer mitochondrial membrane 40-like Neighboring gene STARR-positive B cell enhancer ABC_E1573 Neighboring gene apolipoprotein A-II Neighboring gene Fc receptor, IgE, high affinity I, gamma polypeptide Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene STARR-seq mESC enhancer starr_03024 Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene protoporphyrinogen oxidase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. Glasson SS, et al. Arthritis Rheum, 2004 Aug. PMID 15334469
    2. Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury. Delarue Q, et al. J Neurotrauma, 2020 Feb 1. PMID 31264504
    3. ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis. Lemarchant S, et al. Mol Neurodegener, 2016 Jan 25. PMID 26809777, Free PMC Article
    4. ADAMTS-4 in oligodendrocytes contributes to myelination with an impact on motor function. Pruvost M, et al. Glia, 2017 Dec. PMID 28850711
    5. ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition. Li MD, et al. Commun Biol, 2024 Mar 9. PMID 38461223, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition.
      Title: ADAMTS4 is a crucial proteolytic enzyme for versican cleavage in the amnion at parturition.
    2. Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner.
      Title: Decreased miR-329-3p upregulates Adamts4 and Dnajb1 in mouse hepatic I/R injury in an age-independent manner.
    3. ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRalpha Signaling.
      Title: ADAMTS4 Enhances Oligodendrocyte Differentiation and Remyelination by Cleaving NG2 Proteoglycan and Attenuating PDGFRα Signaling.
    4. ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711.
      Title: ADAMTS4 is involved in the production of the Alzheimer disease amyloid biomarker APP669-711.
    5. Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
      Title: Inhibition of ADAMTS-4 Expression in Olfactory Ensheathing Cells Enhances Recovery after Transplantation within Spinal Cord Injury.
    6. MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
      Title: MiR-126a-5p limits the formation of abdominal aortic aneurysm in mice and decreases ADAMTS-4 expression.
    7. Exuberant fibroblast activity compromises lung function via ADAMTS4.
      Title: Exuberant fibroblast activity compromises lung function via ADAMTS4.
    8. ADAMTS4 was exclusively expressed in oligodendrocytes
      Title: The metalloprotease ADAMTS4 generates N-truncated Aβ4-x species and marks oligodendrocytes as a source of amyloidogenic peptides in Alzheimer's disease.
    9. Aortas in Adamts-4-/- mice showed reduced elastic fiber destruction, versican degradation, macrophage infiltration, and apoptosis. Interestingly, Adamts-4 was directly involved in smooth muscle cell (SMC) apoptosis. Study findings indicate that Adamts-4 induces SMC apoptosis, degrades versican, promotes inflammatory cell infiltration, and thus contributes to sporadic aortic aneurysm and dissection development.
      Title: Critical Role of ADAMTS-4 in the Development of Sporadic Aortic Aneurysm and Dissection in Mice.
    10. host-derived ADAMTS4 was expressed at the tumor vessels and was associated with early-stage tumor growth.
      Title: Host-produced ADAMTS4 Inhibits Early-Stage Tumor Growth.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Gene trapped (1) 
    • Targeted (10)  1 citation

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metallopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protease binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within proteolysis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    A disintegrin and metalloproteinase with thrombospondin motifs 4
    Names
    a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4
    a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4
    aggrecanase-1
    NP_766433.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172845.3 → NP_766433.2  A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein

      Status: REVIEWED

      Source sequence(s)
      AC084821, AC087229, AK083534
      Consensus CDS
      CCDS15485.2
      UniProtKB/Swiss-Prot
      Q8BNJ2, Q8K384
      UniProtKB/TrEMBL
      Q3TNX8
      Related
      ENSMUSP00000106947.4, ENSMUST00000111315.9
      Conserved Domains (6) summary
      smart00209
      Location:527 → 571
      TSP1; Thrombospondin type 1 repeats
      cd04273
      Location:214 → 421
      ZnMc_ADAMTS_like; Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that ...
      pfam01421
      Location:214 → 424
      Reprolysin; Reprolysin (M12B) family zinc metalloprotease
      pfam01562
      Location:74 → 177
      Pep_M12B_propep; Reprolysin family propeptide
      pfam05986
      Location:683 → 798
      ADAM_spacer1; ADAM-TS Spacer 1
      cl15456
      Location:434 → 505
      ADAM_CR; ADAM cysteine-rich

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171077698..171089836
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BNJ2.2 GenPept UniProtKB/Swiss-Prot:Q8BNJ2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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