Rapgef5 Rap guanine nucleotide exchange factor (GEF) 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rapgef5provided by MGI
Official Full Name: Rap guanine nucleotide exchange factor (GEF) 5provided by MGI
Primary source: MGI:MGI:2444365
See related: Ensembl:ENSMUSG00000041992 AllianceGenome:MGI:2444365
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: GFR; Mrgef; mmr-gef; mKIAA0277; 4932413M22; D030051B22Rik
Summary: Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in nuclear body. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart and pericardium; and sensory organ. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in lung adult (RPKM 12.6), cortex adult (RPKM 11.5) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 F2; 12 63.06 cM

Exon count:: 31

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (117480146..117723472)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (117516526..117759737)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rapgef5 (e-PCR), detects polymorphism
- UniSTS:526904

RH127263 (e-PCR)
- UniSTS:209805

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables GTP-dependent protein binding	ISS Inferred from Sequence or Structural Similarity more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nuclear body	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rap guanine nucleotide exchange factor 5

Names: M-Ras-regulated Rap GEF; MR-GEF; Mras regulated guanine nucleotide exchange factor; guanine nucleotide exchange factor for Rap1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001373989.1 → NP_001360918.1 rap guanine nucleotide exchange factor 5 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC139993, AC163283, AC163286

Conserved Domains (3) summary

smart00147
Location:639 → 878

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:367 → 498

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd04437
Location:98 → 221

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
NM_175930.6 → NP_787126.3 rap guanine nucleotide exchange factor 5 isoform 2

See identical proteins and their annotated locations for NP_787126.3

Status: VALIDATED

Source sequence(s)

AC139993, AC163283, AC163286

Consensus CDS

CCDS36577.1

UniProtKB/Swiss-Prot

Q8BJJ9, Q8C0Q9, Q8C0R5

Related

ENSMUSP00000105313.3, ENSMUST00000109691.4

Conserved Domains (3) summary

smart00147
Location:574 → 813

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:302 → 433

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd04437
Location:33 → 156

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

117480146..117723472

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157373.1 → XP_036013266.1 rap guanine nucleotide exchange factor 5 isoform X2

Conserved Domains (2) summary

smart00229
Location:410 → 514

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd04437
Location:141 → 264

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...
XM_030246682.2 → XP_030102542.1 rap guanine nucleotide exchange factor 5 isoform X1

Conserved Domains (3) summary

smart00147
Location:598 → 837

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:326 → 457

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd04437
Location:57 → 180

DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...