Nmur1 neuromedin U receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nmur1provided by RGD
Official Full Name: neuromedin U receptor 1provided by RGD
Primary source: RGD:619867
See related: EnsemblRapid:ENSRNOG00000018521 AllianceGenome:RGD:619867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gpr66; Nmu-r1
Summary: Predicted to enable neuromedin U binding activity and neuromedin U receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; chloride transport; and positive regulation of calcium-mediated signaling. Predicted to be located in membrane. Predicted to be active in cilium and plasma membrane. Orthologous to human NMUR1 (neuromedin U receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 30.3), Spleen (RPKM 4.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q35

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (94480002..94486147, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (87033231..87038070, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (93402871..93407264, complement)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic analysis of the Nmur1 gene in a population of Sprague-Dawley rats revealed that this strain is highly heterogeneous for the inactivating polymorphism.
Title: Functional genomics of the rat neuromedin U receptor 1 reveals a naturally occurring deleterious allele.
NMU stimulates regeneration of rat adrenal cortex, via a mechanism independent of pituitary ACTH and involving the activation of NMUR1 located on adrenocortical cells.
Title: Neuromedin-U stimulates enucleation-induced adrenocortical regeneration in the rat.
endogenous rat NmU receptors couple to both Galpha(q/11) and Galpha(i) G-proteins. Challenge of either circular or longitudinal rat isolated colonic smooth muscle.
Title: Paradoxical behavior of neuromedin U in isolated smooth muscle cells and intact tissue.
NmUR1 but not NmUR2 is specifically expressed in isolated rat pancreatic islets.
Title: Neuromedin U receptor 1 expression in the rat endocrine pancreas and evidence suggesting neuromedin U suppressive effect on insulin secretion from isolated rat pancreatic islets.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables neuromedin U binding	IEA Inferred from Electronic Annotation more info
enables neuromedin U binding	ISO Inferred from Sequence Orthology more info
enables neuromedin U receptor activity	IEA Inferred from Electronic Annotation more info
enables neuromedin U receptor activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in chloride transport	IEA Inferred from Electronic Annotation more info
involved_in chloride transport	ISO Inferred from Sequence Orthology more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuropeptide signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of calcium-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of calcium-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in smooth muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cilium	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuromedin-U receptor 1

Names: G protein-coupled receptor 66; G protein-coupled receptor FM-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023100.2 → NP_075588.2 neuromedin-U receptor 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/TrEMBL

A0A1P0PI13, A0A8I6A0W8

Related

ENSRNOP00000025024.5, ENSRNOT00000025024.7

Conserved Domains (1) summary

pfam00001
Location:64 → 343

7tm_1; 7 transmembrane receptor (rhodopsin family)