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    Bzw1 basic leucine zipper and W2 domains 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363232, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Bzw1provided by RGD
    Official Full Name
    basic leucine zipper and W2 domains 1provided by RGD
    Primary source
    RGD:735129
    See related
    EnsemblRapid:ENSRNOG00000013977 AllianceGenome:RGD:735129
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in regulation of translational initiation. Predicted to be active in cytoplasm. Orthologous to human BZW1 (basic leucine zipper and W2 domains 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 588.9), Brain (RPKM 521.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bzw1 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67424860..67438656)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59930672..59944468)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65279675..65293471)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103690538 Neighboring gene ribosomal protein L21 like 4 Neighboring gene aldehyde oxidase 2 Neighboring gene uncharacterized LOC134480578 Neighboring gene CDC-like kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Purification and functional analysis of a novel leucine-zipper/nucleotide-fold protein, BZAP45, stimulating cell cycle regulated histone H4 gene transcription. Mitra P, et al. Biochemistry, 2001 Sep 4. PMID 11524015
    2. A visual intracellular classification strategy for uncharacterized human proteins. Hoja MR, et al. Exp Cell Res, 2000 Aug 25. PMID 10942595
    3. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    4. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73015

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    eIF5-mimic protein 2
    Names
    basic leucine zipper and W2 domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198789.2 → NP_942084.1  eIF5-mimic protein 2

      See identical proteins and their annotated locations for NP_942084.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061580
      UniProtKB/Swiss-Prot
      Q6P7P5
      UniProtKB/TrEMBL
      A6IP58
      Related
      ENSRNOP00000019486.4, ENSRNOT00000019486.6
      Conserved Domains (1) summary
      cd11560
      Location:217 → 406
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      67424860..67438656
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006245000.5 → XP_006245062.2  eIF5-mimic protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006245062.2

      UniProtKB/TrEMBL
      A0A8I6A479
      Conserved Domains (1) summary
      cd11560
      Location:249 → 438
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    2. XM_017596516.1 → XP_017452005.1  eIF5-mimic protein 2 isoform X2

      Conserved Domains (1) summary
      cd11560
      Location:133 → 322
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P7P5.1 GenPept UniProtKB/Swiss-Prot:Q6P7P5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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