Hes7 hes family bHLH transcription factor 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hes7provided by MGI
Official Full Name: hes family bHLH transcription factor 7provided by MGI
Primary source: MGI:MGI:2135679
See related: Ensembl:ENSMUSG00000023781 AllianceGenome:MGI:2135679
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: bHLHb37
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including negative regulation of transcription by RNA polymerase II; post-anal tail morphogenesis; and somitogenesis. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; descending aorta; small intestine; unsegmented mesenchyme; and urinary system. Used to study spondylocostal dysostosis. Human ortholog(s) of this gene implicated in spondylocostal dysostosis 4. Orthologous to human HES7 (hes family bHLH transcription factor 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 B3; 11 42.38 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (69009778..69014880)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (69118906..69124054)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.
Title: Dynamic Delta-like1 expression in presomitic mesoderm cells during somite segmentation.
Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Title: Species-specific segmentation clock periods are due to differential biochemical reaction speeds.
Hes7 expression in the presomitic mesoderm was up-regulated through the E-box, T-box, and RBPj-binding element in the Hes7 essential region, presumably through synergistic signaling involving mesogenin1, T-box6 (Tbx6), and Notch1.
Title: Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways.
Hes7 oscillation is synchronized between neighboring cells, and the posterior-anterior axis is self-organized as the central-peripheral axis
Title: ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock.
Lengthening the third Hes7 intron by 10 or 20 kb disrupts accurate RNA splicing and inactivates the gene.
Title: Modifying transcript lengths of cycling mouse segmentation genes.
Fgf signaling was found to be a primary target for hypoxia, which causes phenotypic variations of heterozygous mutations in Hes7 or Mesp2, suggesting gene-environment interaction through this signaling.
Title: Oscillatory links of Fgf signaling and Hes7 in the segmentation clock.
Hes7 is a key regulator of the pace of the segmentation clock.
Title: Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene.
Tbx6 and the Wnt pathway cooperatively regulate proper Hes7 expression.
Title: Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock.
introns lead to an approximately 19-min delay in the Hes7 gene expression, and mathematical modeling suggested that without such a delay, Hes7 oscillations would be abolished
Title: Intronic delay is essential for oscillatory expression in the segmentation clock.
there are differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis
Title: Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Targeted (9) 1 citation

General gene information

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Markers

Hes7 (e-PCR), detects polymorphism
- UniSTS:527385

NoName (e-PCR)
- UniSTS:492632

Hes7 (e-PCR), detects polymorphism
- UniSTS:547238

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IC Inferred by Curator more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within post-anal tail morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within rhythmic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within rhythmic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: transcription factor HES-7

Names: bHLH factor Hes7; hairy and enhancer of split 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401507.1 → NP_001388436.1 transcription factor HES-7 isoform 2

Status: VALIDATED

Source sequence(s)

AL645527
NM_033041.5 → NP_149030.2 transcription factor HES-7 isoform 1

See identical proteins and their annotated locations for NP_149030.2

Status: VALIDATED

Source sequence(s)

AL645527

Consensus CDS

CCDS24883.1

UniProtKB/Swiss-Prot

A3KPD3, Q8BKT2, Q99JA6

Related

ENSMUSP00000024543.3, ENSMUST00000024543.3

Conserved Domains (1) summary

cd00083
Location:14 → 73

HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...