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    Lrg1 leucine-rich alpha-2-glycoprotein 1 [ Mus musculus (house mouse) ]

    Gene ID: 76905, updated on 24-Dec-2024

    Summary

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    Official Symbol
    Lrg1provided by MGI
    Official Full Name
    leucine-rich alpha-2-glycoprotein 1provided by MGI
    Primary source
    MGI:MGI:1924155
    See related
    Ensembl:ENSMUSG00000037095 AllianceGenome:MGI:1924155
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lrg; Lrhg; 1300008B03Rik; 2310031E04Rik
    Summary
    Enables transforming growth factor beta receptor binding activity. Acts upstream of or within several processes, including brown fat cell differentiation; positive regulation of endothelial cell proliferation; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in extracellular space. Is expressed in pancreas mesenchyme. Orthologous to human LRG1 (leucine rich alpha-2-glycoprotein 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in liver adult (RPKM 229.9), mammary gland adult (RPKM 136.7) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrg1 in Genome Data Viewer
    Location:
    17 29.17 cM; 17 D
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (56426678..56428946, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (56119678..56121946, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene HDGF like 2 Neighboring gene perilipin 4 Neighboring gene perilipin 5 Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B Neighboring gene STARR-positive B cell enhancer ABC_E5621 Neighboring gene tumor necrosis factor, alpha-induced protein 8-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E7547 Neighboring gene myeloid derived growth factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization. Wang J, et al. Proc Natl Acad Sci U S A, 2024 Aug 27. PMID 39178231,
    2. Leucine-rich α-2-glycoprotein promotes TGFβ1-mediated growth suppression in the Lewis lung carcinoma cell lines. Takemoto N, et al. Oncotarget, 2015 May 10. PMID 25826092, Free PMC Article
    3. Myeloid cell-derived LRG attenuates adverse cardiac remodelling after myocardial infarction. Kumagai S, et al. Cardiovasc Res, 2016 Feb 1. PMID 26678356
    4. Leucine-rich alpha 2 glycoprotein promotes Th17 differentiation and collagen-induced arthritis in mice through enhancement of TGF-β-Smad2 signaling in naïve helper T cells. Urushima H, et al. Arthritis Res Ther, 2017 Jun 14. PMID 28615031, Free PMC Article
    5. Leucine-rich α2-glycoprotein overexpression in the brain contributes to memory impairment. Akiba C, et al. Neurobiol Aging, 2017 Dec. PMID 28917663

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LRG1 loss effectively restrains glomerular TGF-beta signaling to attenuate diabetic kidney disease.
      Title: LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate diabetic kidney disease.
    2. LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization.
      Title: LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization.
    3. Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFbeta1- Smad1/5 signaling pathway.
      Title: Lrg1 silencing attenuates ischemia-reperfusion renal injury by regulating autophagy and apoptosis through the TGFβ1- Smad1/5 signaling pathway.
    4. Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
      Title: Exosome enriched leucine-rich alpha-2-glycoprotein-1 and extracellular matrix protein 1 proteins induce abnormal placental angiogenesis in pregnant mice.
    5. Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia-reperfusion injury by modulating various cells.
      Title: Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells.
    6. Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
      Title: Crystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation.
    7. LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation.
      Title: LRG1 is an adipokine that promotes insulin sensitivity and suppresses inflammation.
    8. LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
      Title: LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency.
    9. Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFbeta1)/SMAD signaling pathway.
      Title: Leucine rich alpha-2-glycoprotein 1 (Lrg1) silencing protects against sepsis-mediated brain injury by inhibiting transforming growth factor beta1 (TGFβ1)/SMAD signaling pathway.
    10. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.
      Title: LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.
    Submit: New GeneRIF Correction See all GeneRIFs (31)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 
    • Targeted (2)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102387

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables potassium channel activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transforming growth factor beta receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables type I transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables type II transforming growth factor beta receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables voltage-gated potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within brown fat cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of keratinocyte migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of leukocyte adhesion to vascular endothelial cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of angiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of angiogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of positive regulation of endothelial cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of epithelial cell proliferation involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of epithelial to mesenchymal transition ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of positive regulation of keratinocyte proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    leucine-rich alpha-2-glycoprotein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_029796.2 → NP_084072.1  leucine-rich alpha-2-glycoprotein precursor

      See identical proteins and their annotated locations for NP_084072.1

      Status: PROVISIONAL

      Source sequence(s)
      BC030733
      Consensus CDS
      CCDS28895.1
      UniProtKB/TrEMBL
      Q91XL1
      Related
      ENSMUSP00000038048.8, ENSMUST00000041357.9
      Conserved Domains (4) summary
      smart00082
      Location:292 → 338
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:74 → 294
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00033
      Location:65 → 86
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:109 → 169
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      56426678..56428946 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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