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    Bcl2l14 BCL2 like 14 [ Mus musculus (house mouse) ]

    Gene ID: 66813, updated on 9-Dec-2024

    Summary

    Official Symbol
    Bcl2l14provided by MGI
    Official Full Name
    BCL2 like 14provided by MGI
    Primary source
    MGI:MGI:1914063
    See related
    Ensembl:ENSMUSG00000030200 AllianceGenome:MGI:1914063
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bclg; Bcl-G; 4930452K23Rik; 4933405K19Rik; 9030625M01Rik
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to act upstream of or within regulation of apoptotic process. Predicted to be located in cytosol. Is expressed in early embryo; genitourinary system; gut; and submandibular gland primordium. Orthologous to human BCL2L14 (BCL2 like 14). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 24.0), duodenum adult (RPKM 4.4) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Bcl2l14 in Genome Data Viewer
    Location:
    6 G1; 6 65.22 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (134373292..134415687)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (134396329..134438724)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene ets variant 6 Neighboring gene RIKEN cDNA 1700051K13 gene Neighboring gene STARR-seq mESC enhancer starr_17540 Neighboring gene predicted gene 17089 Neighboring gene RIKEN cDNA 4933406J09 gene Neighboring gene STARR-positive B cell enhancer mm9_chr6:134288078-134288378 Neighboring gene STARR-seq mESC enhancer starr_17542 Neighboring gene STARR-positive B cell enhancer ABC_E10413 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134339435-134339735 Neighboring gene STARR-seq mESC enhancer starr_17545 Neighboring gene low density lipoprotein receptor-related protein 6 Neighboring gene STARR-seq mESC enhancer starr_17546 Neighboring gene STARR-positive B cell enhancer mm9_chr6:134565289-134565590 Neighboring gene MANSC domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    involved_in positive regulation of extrinsic apoptotic signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within regulation of apoptotic process RCA
    inferred from Reviewed Computational Analysis
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    apoptosis facilitator Bcl-2-like protein 14
    Names
    BCL2-like 14 (apoptosis facilitator)
    apoptosis regulator BCL-G

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355686.1NP_001342615.1  apoptosis facilitator Bcl-2-like protein 14

      Status: VALIDATED

      Source sequence(s)
      AC155838, AK018579
      Consensus CDS
      CCDS20636.1
      UniProtKB/Swiss-Prot
      Q3TVA7, Q8R141, Q9CPT0, Q9D3W3
      Related
      ENSMUSP00000107591.2, ENSMUST00000111960.2
      Conserved Domains (1) summary
      cl02575
      Location:293316
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...
    2. NM_025778.3NP_080054.1  apoptosis facilitator Bcl-2-like protein 14

      See identical proteins and their annotated locations for NP_080054.1

      Status: VALIDATED

      Source sequence(s)
      AC155838
      Consensus CDS
      CCDS20636.1
      UniProtKB/Swiss-Prot
      Q3TVA7, Q8R141, Q9CPT0, Q9D3W3
      Related
      ENSMUSP00000032321.5, ENSMUST00000032321.11
      Conserved Domains (1) summary
      cl02575
      Location:293316
      Bcl-2_like; Apoptosis regulator proteins of the Bcl-2 family, named after B-cell lymphoma 2. This alignment model spans what have been described as Bcl-2 homology regions BH1, BH2, BH3, and BH4. Many members of this family have an additional C-terminal transmembrane ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      134373292..134415687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)