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    Gpr35 G protein-coupled receptor 35 [ Mus musculus (house mouse) ]

    Gene ID: 64095, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gpr35provided by MGI
    Official Full Name
    G protein-coupled receptor 35provided by MGI
    Primary source
    MGI:MGI:1929509
    See related
    Ensembl:ENSMUSG00000026271 AllianceGenome:MGI:1929509
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    KPG_007
    Summary
    Predicted to enable C-X-C chemokine receptor activity. Involved in cytoskeleton organization. Located in plasma membrane. Is expressed in adipose tissue; bone; gut; lower urinary tract; and spleen. Orthologous to human GPR35 (G protein-coupled receptor 35). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in colon adult (RPKM 5.6), spleen adult (RPKM 3.2) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpr35 in Genome Data Viewer
    Location:
    1 D; 1 46.65 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (92875774..92913984)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (92948052..92986391)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 5033417F24 gene Neighboring gene arginyl aminopeptidase (aminopeptidase B)-like 1 Neighboring gene STARR-seq mESC enhancer starr_01722 Neighboring gene RIKEN cDNA 9430060I03 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:94830898-94831081 Neighboring gene STARR-positive B cell enhancer ABC_E4335 Neighboring gene calpain 10 Neighboring gene predicted gene, 36424 Neighboring gene trans-acting transcription factor 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Novel Role of GPR35 (G-Protein-Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure. Li H, et al. Hypertension, 2021 Sep. PMID 34275335, Free PMC Article
    2. The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice. Divorty N, et al. Am J Hypertens, 2018 Aug 3. PMID 29860395, Free PMC Article
    3. Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation. Agudelo LZ, et al. Cell Metab, 2018 Feb 6. PMID 29414686
    4. G protein-coupled receptor 35 contributes to mucosal repair in mice via migration of colonic epithelial cells. Tsukahara T, et al. Pharmacol Res, 2017 Sep. PMID 28648739
    5. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages. Sharmin O, et al. Sci Rep, 2020 Jun 10. PMID 32523084, Free PMC Article

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior.
      Title: A Gpr35-tuned gut microbe-brain metabolic axis regulates depressive-like behavior.
    2. Gpr35 shapes gut microbial ecology to modulate hepatic steatosis.
      Title: Gpr35 shapes gut microbial ecology to modulate hepatic steatosis.
    3. Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
      Title: Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists.
    4. GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
      Title: GPR35 promotes neutrophil recruitment in response to serotonin metabolite 5-HIAA.
    5. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity.
      Title: Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity.
    6. Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-kappaB signaling pathway.
      Title: Kynurenic acid ameliorates lipopolysaccharide-induced endometritis by regulating the GRP35/NF-κB signaling pathway.
    7. GPR35 regulates osteogenesis via the Wnt/GSK3beta/beta-catenin signaling pathway.
      Title: GPR35 regulates osteogenesis via the Wnt/GSK3β/β-catenin signaling pathway.
    8. Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1(+) Macrophages Regulates Intestinal Homeostasis.
      Title: Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1(+) Macrophages Regulates Intestinal Homeostasis.
    9. Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
      Title: Activation of GPR35 protects against cerebral ischemia by recruiting monocyte-derived macrophages.
    10. Data suggest that G protein-coupled receptor 35 (GPR35 ) acts as a central signaling and metabolic pacesetter, which reveals an unexpected role of sodium potassium pump (Na/K-ATPase) in macrophage and intestinal epithelial cells (IECs) biology.
      Title: GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables C-X-C chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables C-X-C chemokine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G protein-coupled receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables G protein-coupled receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables chemokine receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in chemokine-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in chemokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in macrophage chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neuronal action potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of neuronal action potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of voltage-gated calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in positive regulation of cytosolic calcium ion concentration ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    G-protein coupled receptor 35
    Names
    KYNA receptor
    kynurenic acid receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104529.2 → NP_001097999.1  G-protein coupled receptor 35

      See identical proteins and their annotated locations for NP_001097999.1

      Status: VALIDATED

      Source sequence(s)
      AC119846
      Consensus CDS
      CCDS15182.1
      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97
      Related
      ENSMUSP00000139648.2, ENSMUST00000186298.7
      Conserved Domains (1) summary
      cd15164
      Location:35 → 286
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. NM_001271766.2 → NP_001258695.1  G-protein coupled receptor 35

      See identical proteins and their annotated locations for NP_001258695.1

      Status: VALIDATED

      Source sequence(s)
      AC119846
      Consensus CDS
      CCDS15182.1
      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97
      Related
      ENSMUSP00000070832.7, ENSMUST00000064480.7
      Conserved Domains (1) summary
      cd15164
      Location:35 → 286
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. NM_001412853.1 → NP_001399782.1  G-protein coupled receptor 35

      Status: VALIDATED

      Source sequence(s)
      AC119846
      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97

    4. NM_022320.5 → NP_071715.3  G-protein coupled receptor 35

      See identical proteins and their annotated locations for NP_071715.3

      Status: VALIDATED

      Source sequence(s)
      AC119846
      Consensus CDS
      CCDS15182.1
      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97
      Related
      ENSMUSP00000126914.2, ENSMUST00000169198.3
      Conserved Domains (1) summary
      cd15164
      Location:35 → 286
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      92875774..92913984
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529780.4 → XP_006529843.1  G-protein coupled receptor 35 isoform X2

      See identical proteins and their annotated locations for XP_006529843.1

      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97
      Conserved Domains (1) summary
      cd15164
      Location:35 → 286
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    2. XM_011248053.4 → XP_011246355.1  G-protein coupled receptor 35 isoform X2

      See identical proteins and their annotated locations for XP_011246355.1

      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97
      Conserved Domains (1) summary
      cd15164
      Location:35 → 286
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    3. XM_006529777.4 → XP_006529840.1  G-protein coupled receptor 35 isoform X1

      UniProtKB/TrEMBL
      Q8CB97
      Conserved Domains (1) summary
      cd15164
      Location:41 → 292
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    4. XM_006529779.5 → XP_006529842.1  G-protein coupled receptor 35 isoform X2

      See identical proteins and their annotated locations for XP_006529842.1

      UniProtKB/Swiss-Prot
      Q9ES90
      UniProtKB/TrEMBL
      Q3TBY9, Q8CB97
      Conserved Domains (1) summary
      cd15164
      Location:35 → 286
      7tmA_GPR35-like; G protein-coupled receptor 35 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ES90.1 GenPept UniProtKB/Swiss-Prot:Q9ES90

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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