Poglut3 protein O-glucosyltransferase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Poglut3provided by MGI
Official Full Name: protein O-glucosyltransferase 3provided by MGI
Primary source: MGI:MGI:1923765
See related: Ensembl:ENSMUSG00000034487 AllianceGenome:MGI:1923765
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Kdelc2; 2010004J24Rik; 4833410J10Rik
Summary: Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Is expressed in liver and white fat. Orthologous to human POGLUT3 (protein O-glucosyltransferase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 6.7), bladder adult (RPKM 5.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.3; 9 29.12 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (53294217..53313167)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (53383004..53401867)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.
Title: Poglut2/3 double knockout in mice results in neonatal lethality with reduced levels of fibrillin in lung tissues.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Kdelc2 (e-PCR), detects polymorphism
- UniSTS:547990

AW549401 (e-PCR)
- UniSTS:179898

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables EGF-domain serine glucosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables EGF-domain serine xylosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables UDP-glucosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-glucosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables UDP-xylosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables UDP-xylosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables glucosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in protein O-linked glycosylation via serine	ISO Inferred from Sequence Orthology more info
involved_in protein O-linked glycosylation via serine	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein O-glucosyltransferase 3

Names: KDEL (Lys-Asp-Glu-Leu) containing 2; KDEL motif-containing protein 2; protein O-xylosyltransferase POGLUT3

NP_997610.1

EC 2.4.2.26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212445.2 → NP_997610.1 protein O-glucosyltransferase 3 precursor

See identical proteins and their annotated locations for NP_997610.1

Status: VALIDATED

Source sequence(s)

AC079869, AK019513, AK020078, AK075811, AK076412

Consensus CDS

CCDS23182.1

UniProtKB/Swiss-Prot

G5E897, Q8C6F3

Related

ENSMUSP00000039313.4, ENSMUST00000037853.5

Conserved Domains (3) summary

smart00557
Location:24 → 128

IG_FLMN; Filamin-type immunoglobulin domains

pfam00630
Location:22 → 126

Filamin; Filamin/ABP280 repeat

cl23835
Location:147 → 481

Glyco_transf_90; Glycosyl transferase family 90