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    Cdc42se2 CDC42 small effector 2 [ Mus musculus (house mouse) ]

    Gene ID: 72729, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cdc42se2provided by MGI
    Official Full Name
    CDC42 small effector 2provided by MGI
    Primary source
    MGI:MGI:1919979
    See related
    Ensembl:ENSMUSG00000052298 AllianceGenome:MGI:1919979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SPEC2; 2810404F18Rik
    Summary
    Predicted to enable signaling adaptor activity. Predicted to be involved in regulation of signal transduction. Predicted to be located in several cellular components, including cell projection; cytoskeleton; and phagocytic cup. Predicted to be active in plasma membrane. Orthologous to human CDC42SE2 (CDC42 small effector 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in frontal lobe adult (RPKM 40.6), large intestine adult (RPKM 40.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc42se2 in Genome Data Viewer
    Location:
    11 B1.3; 11 32.13 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (54608241..54678549, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (54717415..54787703, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57579 Neighboring gene folliculin interacting protein 1 Neighboring gene predicted gene, 24198 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54336045-54336232 Neighboring gene STARR-positive B cell enhancer ABC_E6984 Neighboring gene Rap guanine nucleotide exchange factor (GEF) 6 Neighboring gene STARR-seq mESC enhancer starr_29509 Neighboring gene STARR-seq mESC enhancer starr_29510 Neighboring gene predicted gene 12227 Neighboring gene STARR-positive B cell enhancer ABC_E8404 Neighboring gene STARR-positive B cell enhancer ABC_E11480 Neighboring gene STARR-positive B cell enhancer ABC_E6985 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:54615437-54615636 Neighboring gene STARR-positive B cell enhancer ABC_E2988 Neighboring gene STARR-seq mESC enhancer starr_29513 Neighboring gene LYR motif containing 7, opposite strand Neighboring gene LYR motif containing 7 Neighboring gene ATPase family, AAA domain containing 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
    5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables signaling adaptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in phagocytic cup IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    CDC42 small effector protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178626.3 → NP_848741.1  CDC42 small effector protein 2

      See identical proteins and their annotated locations for NP_848741.1

      Status: VALIDATED

      Source sequence(s)
      AK135775, AK160934, BY688282, CJ072588
      Consensus CDS
      CCDS36153.1
      UniProtKB/Swiss-Prot
      Q3UKN9, Q8BGH7
      Related
      ENSMUSP00000070725.7, ENSMUST00000064104.13
      Conserved Domains (1) summary
      cd00132
      Location:27 → 67
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      54608241..54678549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534320.4 → XP_006534383.1  CDC42 small effector protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006534383.1

      UniProtKB/Swiss-Prot
      Q3UKN9, Q8BGH7
      Conserved Domains (1) summary
      cd00132
      Location:27 → 67
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    2. XM_030246369.2 → XP_030102229.1  CDC42 small effector protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UKN9, Q8BGH7
      Conserved Domains (1) summary
      cd00132
      Location:27 → 67
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    3. XM_030246370.1 → XP_030102230.1  CDC42 small effector protein 2 isoform X1

      UniProtKB/Swiss-Prot
      Q3UKN9, Q8BGH7
      Conserved Domains (1) summary
      cd00132
      Location:27 → 67
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BGH7.1 GenPept UniProtKB/Swiss-Prot:Q8BGH7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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