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    Frs2 fibroblast growth factor receptor substrate 2 [ Mus musculus (house mouse) ]

    Gene ID: 327826, updated on 9-Dec-2024

    Summary

    Official Symbol
    Frs2provided by MGI
    Official Full Name
    fibroblast growth factor receptor substrate 2provided by MGI
    Primary source
    MGI:MGI:1100860
    See related
    Ensembl:ENSMUSG00000020170 AllianceGenome:MGI:1100860
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SNT1; SNT-1; Frs2alpha; FRS2-alpha; C330018A15Rik
    Summary
    Enables transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within several processes, including camera-type eye development; nervous system development; and regulation of MAPK cascade. Located in cell-cell junction; cytoplasm; and plasma membrane. Is expressed in several structures, including blastocyst; central nervous system; genitourinary system; gut; and immune system. Orthologous to human FRS2 (fibroblast growth factor receptor substrate 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 13.1), CNS E14 (RPKM 10.3) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Frs2 in Genome Data Viewer
    Location:
    10 D2; 10 65.09 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (116905324..116986311, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (117070127..117148474, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 10 Neighboring gene STARR-positive B cell enhancer ABC_E2966 Neighboring gene chaperonin containing TCP1 subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E8366 Neighboring gene STARR-seq mESC enhancer starr_27971 Neighboring gene predicted gene, 40811 Neighboring gene predicted gene, 53635 Neighboring gene RIKEN cDNA 4930423D24 gene Neighboring gene predicted gene, 40769

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables fibroblast growth factor receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables neurotrophin TRKA receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables neurotrophin TRKA receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transmembrane receptor protein tyrosine kinase adaptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within anterior/posterior axis specification, embryo IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within cell surface receptor protein tyrosine kinase signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to fibroblast growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within forebrain development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within gastrulation with mouth forming second IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens development in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within lens fiber cell development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within lens placode formation involved in camera-type eye formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of cardiac muscle cell differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within neuroblast proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within neuroblast proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within organ induction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of epithelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within ventricular septum development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in adherens junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in adherens junction ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibroblast growth factor receptor substrate 2
    Names
    FGFR substrate 2
    FGFR-signaling adaptor SNT
    suc1-associated neurotrophic factor target 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408282.1NP_001395211.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    2. NM_001408283.1NP_001395212.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    3. NM_001408284.1NP_001395213.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    4. NM_001408285.1NP_001395214.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    5. NM_001408286.1NP_001395215.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    6. NM_001408287.1NP_001395216.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    7. NM_001408288.1NP_001395217.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    8. NM_001408289.1NP_001395218.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    9. NM_001408290.1NP_001395219.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    10. NM_001408291.1NP_001395220.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    11. NM_001408292.1NP_001395221.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    12. NM_001408293.1NP_001395222.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    13. NM_001408294.1NP_001395223.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    14. NM_001408295.1NP_001395224.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    15. NM_001408296.1NP_001395225.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    16. NM_001408297.1NP_001395226.1  fibroblast growth factor receptor substrate 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      UniProtKB/Swiss-Prot
      Q8C180
    17. NM_001408308.1NP_001395237.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    18. NM_001408309.1NP_001395238.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    19. NM_001408310.1NP_001395239.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    20. NM_001408311.1NP_001395240.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    21. NM_001408312.1NP_001395241.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    22. NM_001408313.1NP_001395242.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    23. NM_001408314.1NP_001395243.1  fibroblast growth factor receptor substrate 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL589661
    24. NM_177798.4NP_808466.1  fibroblast growth factor receptor substrate 2 isoform 1

      See identical proteins and their annotated locations for NP_808466.1

      Status: VALIDATED

      Source sequence(s)
      AL589661
      Consensus CDS
      CCDS24190.1
      UniProtKB/Swiss-Prot
      Q8C180
      Related
      ENSMUSP00000020381.4, ENSMUST00000020381.5
      Conserved Domains (1) summary
      cd01202
      Location:15106
      PTB_FRS2; Fibroblast growth factor receptor substrate 2 phosphotyrosine-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      116905324..116986311 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)