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    Nckap5 NCK-associated protein 5 [ Mus musculus (house mouse) ]

    Gene ID: 210356, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Nckap5provided by MGI
    Official Full Name
    NCK-associated protein 5provided by MGI
    Primary source
    MGI:MGI:2686394
    See related
    Ensembl:ENSMUSG00000049690 AllianceGenome:MGI:2686394
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Nap5; Erih1; Erih2; Gm1548; 8430408F21; D130011D22Rik; E030049G20Rik
    Summary
    Predicted to be involved in microtubule bundle formation and microtubule depolymerization. Predicted to be active in microtubule plus-end. Is expressed in central nervous system; lung; and sensory organ. Orthologous to human NCKAP5 (NCK associated protein 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 4.1), CNS E18 (RPKM 1.4) and 13 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nckap5 in Genome Data Viewer
    Location:
    1 E3; 1 54.7 cM
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (125841373..126758529, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (125913636..126830796, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 39 Neighboring gene predicted gene, 41943 Neighboring gene Ly6/Plaur domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_02114 Neighboring gene predicted gene, 35562 Neighboring gene STARR-seq mESC enhancer starr_02115 Neighboring gene STARR-seq mESC enhancer starr_02116 Neighboring gene RIKEN cDNA 4930599A14 gene Neighboring gene STARR-seq mESC enhancer starr_02117 Neighboring gene predicted gene, 41945

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Telencephalic embryonic subtractive sequences: a unique collection of neurodevelopmental genes. Bulfone A, et al. J Neurosci, 2005 Aug 17. PMID 16107646, Free PMC Article
    2. Transcriptome analysis of mouse stem cells and early embryos. Sharov AA, et al. PLoS Biol, 2003 Dec. PMID 14691545, Free PMC Article
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90557

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule bundle formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in microtubule plus-end IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    nck-associated protein 5
    Names
    peripheral clock protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081756.1 → NP_001075225.1  nck-associated protein 5 isoform 1

      See identical proteins and their annotated locations for NP_001075225.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).
      Source sequence(s)
      AK053243, BC066095, CN700744
      Consensus CDS
      CCDS35695.1
      UniProtKB/TrEMBL
      E9QAE1, F6VHY8, Q29SA9
      Related
      ENSMUSP00000108202.2, ENSMUST00000112583.8
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    2. NM_172484.3 → NP_766072.2  nck-associated protein 5 isoform 2

      See identical proteins and their annotated locations for NP_766072.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and a protein (isoform 2) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK053243, BC066095
      Consensus CDS
      CCDS48345.1
      UniProtKB/TrEMBL
      F6VHY8, Q29SA9, Q6NZK2
      Related
      ENSMUSP00000125624.2, ENSMUST00000161954.8
      Conserved Domains (2) summary
      pfam15246
      Location:1363 → 1665
      NCKAP5; Nck-associated protein 5, Peripheral clock protein
      cl23720
      Location:2 → 89
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

    3. NM_176957.3 → NP_795931.2  nck-associated protein 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks several segments in the coding region, compared to variant 1, one of which results in a translational frameshift. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
      Source sequence(s)
      AK053243, BC066095, CN700744
      Consensus CDS
      CCDS48346.1
      UniProtKB/TrEMBL
      E9Q3G9, Q8C6S8
      Related
      ENSMUSP00000092192.4, ENSMUST00000094609.10
      Conserved Domains (1) summary
      pfam15246
      Location:271 → 363
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      125841373..126758529 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163201.1 → XP_036019094.1  nck-associated protein 5 isoform X10

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:741 → 952
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:57 → 254
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1367 → 1669
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    2. XM_030252625.2 → XP_030108485.1  nck-associated protein 5 isoform X7

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:741 → 952
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:57 → 254
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1367 → 1669
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    3. XM_006529326.5 → XP_006529389.1  nck-associated protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006529389.1

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    4. XM_006529330.5 → XP_006529393.1  nck-associated protein 5 isoform X4

      See identical proteins and their annotated locations for XP_006529393.1

      UniProtKB/TrEMBL
      E9QAE1, F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    5. XM_006529336.5 → XP_006529399.1  nck-associated protein 5 isoform X13

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    6. XM_006529329.5 → XP_006529392.1  nck-associated protein 5 isoform X2

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    7. XM_006529334.5 → XP_006529397.1  nck-associated protein 5 isoform X11

      See identical proteins and their annotated locations for XP_006529397.1

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    8. XM_006529325.5 → XP_006529388.1  nck-associated protein 5 isoform X1

      See identical proteins and their annotated locations for XP_006529388.1

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    9. XM_011247963.4 → XP_011246265.1  nck-associated protein 5 isoform X16

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:839 → 1050
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:57 → 254
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1465 → 1767
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    10. XM_011247958.4 → XP_011246260.1  nck-associated protein 5 isoform X3

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:780 → 991
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:19 → 234
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1406 → 1708
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    11. XM_030252637.2 → XP_030108497.1  nck-associated protein 5 isoform X15

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Related
      ENSMUSP00000062229.9, ENSMUST00000057846.15
      Conserved Domains (3) summary
      PHA03247
      Location:673 → 884
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3 → 186
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1299 → 1601
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    12. XM_006529332.4 → XP_006529395.1  nck-associated protein 5 isoform X8

      See identical proteins and their annotated locations for XP_006529395.1

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:737 → 948
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3 → 208
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1363 → 1665
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    13. XM_036163204.1 → XP_036019097.1  nck-associated protein 5 isoform X12

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:708 → 919
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:24 → 221
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1334 → 1636
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    14. XM_011247959.3 → XP_011246261.1  nck-associated protein 5 isoform X5

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:772 → 983
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:16 → 226
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1398 → 1700
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    15. XM_036163207.1 → XP_036019100.1  nck-associated protein 5 isoform X15

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:673 → 884
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3 → 186
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1299 → 1601
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    16. XM_011247960.3 → XP_011246262.1  nck-associated protein 5 isoform X6

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:765 → 976
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:4 → 219
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1391 → 1693
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    17. XM_030252628.2 → XP_030108488.1  nck-associated protein 5 isoform X8

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:737 → 948
      PHA03247; large tegument protein UL36; Provisional
      TIGR02168
      Location:3 → 208
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15246
      Location:1363 → 1665
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    18. XM_036163206.1 → XP_036019099.1  nck-associated protein 5 isoform X14

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    19. XM_036163199.1 → XP_036019092.1  nck-associated protein 5 isoform X9

      UniProtKB/TrEMBL
      F6VHY8, Q29SA9
      Conserved Domains (3) summary
      PHA03247
      Location:805 → 1016
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:44 → 259
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam15246
      Location:1431 → 1733
      NCKAP5; Nck-associated protein 5, Peripheral clock protein

    RNA

    1. XR_004941376.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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