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    Tsg101 tumor susceptibility gene 101 [ Mus musculus (house mouse) ]

    Gene ID: 22088, updated on 4-Jan-2025

    Summary

    Official Symbol
    Tsg101provided by MGI
    Official Full Name
    tumor susceptibility gene 101provided by MGI
    Primary source
    MGI:MGI:106581
    See related
    Ensembl:ENSMUSG00000014402 AllianceGenome:MGI:106581
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CC2
    Summary
    Enables transcription corepressor activity. Involved in exosomal secretion; positive regulation of ubiquitin-dependent endocytosis; and viral budding. Acts upstream of or within several processes, including keratinocyte differentiation; negative regulation of transcription by RNA polymerase II; and regulation of cell growth. Located in cytoplasm and extracellular exosome. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; limb; and nervous system. Human ortholog(s) of this gene implicated in breast cancer; breast carcinoma; cervix carcinoma; endometrial adenocarcinoma; and prostate cancer. Orthologous to human TSG101 (tumor susceptibility 101). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 29.9), CNS E14 (RPKM 28.1) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Tsg101 in Genome Data Viewer
    Location:
    7 B3; 7 30.62 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46538693..46569716, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46888949..46926320, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A Neighboring gene predicted gene, 39011 Neighboring gene lactate dehydrogenase C Neighboring gene STARR-seq mESC enhancer starr_18876 Neighboring gene UEV and lactate/malate dehyrogenase domains Neighboring gene predicted gene, 39012 Neighboring gene thymosin, beta 10 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium-dependent protein binding  
    enables calcium-dependent protein binding  
    enables nuclear receptor coactivator activity  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein homodimerization activity  
    enables protein-containing complex binding  
    enables protein-containing complex binding  
    enables transcription corepressor activity PubMed 
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables ubiquitin binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding  
    enables virion binding  
    enables virion binding  
    Items 1 - 25 of 32
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation PubMed 
    involved_in cell division  
    involved_in endosome to lysosome transport  
    involved_in endosome to lysosome transport  
    involved_in exosomal secretion PubMed 
    involved_in extracellular transport  
    involved_in extracellular transport  
    acts_upstream_of_or_within keratinocyte differentiation PubMed 
    acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor receptor signaling pathway  
    involved_in negative regulation of epidermal growth factor-activated receptor activity  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
    involved_in positive regulation of exosomal secretion  
    involved_in positive regulation of exosomal secretion  
    involved_in positive regulation of ubiquitin-dependent endocytosis PubMed 
    involved_in positive regulation of viral budding via host ESCRT complex  
    involved_in positive regulation of viral budding via host ESCRT complex  
    involved_in protein modification process  
    involved_in protein monoubiquitination  
    involved_in protein transport  
    involved_in regulation of MAP kinase activity  
    acts_upstream_of_or_within regulation of cell cycle PubMed 
    acts_upstream_of_or_within regulation of cell growth PubMed 
    involved_in regulation of extracellular exosome assembly  
    involved_in regulation of extracellular exosome assembly  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    involved_in viral budding PubMed 
    involved_in viral budding  
    involved_in viral release from host cell  
    involved_in viral release from host cell  
    Items 1 - 25 of 32
    Items 1 - 20 of 23
    Component Evidence Code Pubs
    part_of ESCRT I complex  
    part_of ESCRT I complex  
    part_of ESCRT I complex  
    part_of ESCRT I complex PubMed 
    located_in Flemming body  
    located_in centrosome  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    located_in early endosome  
    located_in early endosome membrane  
    located_in endosome  
    located_in endosome membrane  
    located_in extracellular exosome PubMed 
    located_in extracellular exosome  
    located_in late endosome  
    located_in late endosome membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    Items 1 - 20 of 23

    General protein information

    Preferred Names
    tumor susceptibility gene 101 protein
    Names
    ESCRT-I complex subunit TSG101

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348088.2NP_001335017.1  tumor susceptibility gene 101 protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate exons in the coding region compared to variant 1. The encoded isoform (2) is shorter compared to isoform 1.
      Source sequence(s)
      AC090123
      UniProtKB/TrEMBL
      Q3UK08
      Conserved Domains (3) summary
      TIGR02168
      Location:189331
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05743
      Location:21139
      UEV; UEV domain
      pfam09454
      Location:264323
      Vps23_core; Vps23 core domain
    2. NM_001348089.2NP_001335018.1  tumor susceptibility gene 101 protein isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in the 5' region and uses a downstream start codon compared to variant 1. It encodes isoform 3 which has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC090123
      UniProtKB/TrEMBL
      A0A1B0GS09
      Conserved Domains (3) summary
      TIGR02168
      Location:148290
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09454
      Location:223282
      Vps23_core; Vps23 core domain
      cl00154
      Location:145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    3. NM_001417440.1NP_001404369.1  tumor susceptibility gene 101 protein isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC090123
      UniProtKB/TrEMBL
      Q3UK08
    4. NM_021884.5NP_068684.1  tumor susceptibility gene 101 protein isoform 1

      See identical proteins and their annotated locations for NP_068684.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC090123
      Consensus CDS
      CCDS21291.1
      UniProtKB/Swiss-Prot
      Q61187
      UniProtKB/TrEMBL
      Q3UCW0, Q3UK08
      Related
      ENSMUSP00000014546.9, ENSMUST00000014546.15
      Conserved Domains (3) summary
      TIGR02168
      Location:242384
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam05743
      Location:21139
      UEV; UEV domain
      pfam09454
      Location:317376
      Vps23_core; Vps23 core domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46538693..46569716 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242362.2XP_030098222.1  tumor susceptibility gene 101 protein isoform X1

      UniProtKB/TrEMBL
      A0A1B0GS09
      Related
      ENSMUSP00000147748.2, ENSMUST00000209538.2
      Conserved Domains (3) summary
      TIGR02168
      Location:95237
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam09454
      Location:170229
      Vps23_core; Vps23 core domain
      cl00154
      Location:145
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
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