Jam3 junction adhesion molecule 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Jam3provided by MGI
Official Full Name: junction adhesion molecule 3provided by MGI
Primary source: MGI:MGI:1933825
See related: Ensembl:ENSMUSG00000031990 AllianceGenome:MGI:1933825
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JAM-3; JAM-C; Jcam3; 1110002N23Rik
Summary: Enables identical protein binding activity and integrin binding activity. Involved in angiogenesis; cell-cell adhesion; and hematopoietic stem cell migration to bone marrow. Acts upstream of or within several processes, including leukocyte migration involved in inflammatory response; myeloid progenitor cell differentiation; and regulation of actin cytoskeleton organization by cell-cell adhesion. Located in Schmidt-Lanterman incisure; bicellular tight junction; and paranodal junction. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and immune system. Orthologous to human JAM3 (junctional adhesion molecule 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in CNS E11.5 (RPKM 37.0), limb E14.5 (RPKM 30.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A4; 9 12.27 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (27008680..27066739, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (27097384..27155421, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.
Title: JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens Fiber Maturation in Murine Lens Development.
Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans.
Title: Junctional adhesion molecule C expression specifies a CD138low/neg multiple myeloma cell population in mice and humans.
Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis.
Title: Junctional Adhesion Molecule-C Mediates the Recruitment of Embryonic-Endothelial Progenitor Cells to the Perivascular Niche during Tumor Angiogenesis.
CIRP induces neutrophil reverse transendothelial migration in sepsis by increasing neutrophil elastase and decreasing junctional adhesion molecule-C
Title: CIRP Induces Neutrophil Reverse Transendothelial Migration in Sepsis.
Jam-c gene deletion resulted in smaller eyes and decreased photoreceptor numbers.
Title: Neuronal Expression of Junctional Adhesion Molecule-C is Essential for Retinal Thickness and Photoreceptor Survival.
The role of JAM-C on the aging of neutrophils to cause sepsis-induced acute lung injury was studied. JAM-C not only regulates neutrophil chemotaxis but also prolongs their survival by promoting anti-apoptotic function.
Title: Targeting junctional adhesion molecule-C ameliorates sepsis-induced acute lung injury by decreasing CXCR4(+) aged neutrophils.
this study shows that JAM-C promotes autoimmune-mediated liver fibrosis in mice
Title: Junctional adhesion molecules JAM-B and JAM-C promote autoimmune-mediated liver fibrosis in mice.
the dimerization sites E66-K68 of JAM-C affected cell adhesion, polarization and migration and are essential for tumor cell metastasis.
Title: Junctional adhesion molecule C (JAM-C) dimerization aids cancer cell migration and metastasis.
JAM-C plays an important role in maintaining VEGR2 expression to promote retinal pigment epithelial cell survival under oxidative stress.
Title: JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress.
JAM-B/JAM-C mediated interaction between endothelial cells and stellate cells stabilizes vessel walls and may control the sinusoidal diameter.
Title: Murine junctional adhesion molecules JAM-B and JAM-C mediate endothelial and stellate cell interactions during hepatic fibrosis.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236082

Jam3 (e-PCR), detects polymorphism
- UniSTS:516177

RH127200 (e-PCR)
- UniSTS:209796

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cell-cell adhesion mediator activity	IBA Inferred from Biological aspect of Ancestor more info
enables cell-cell adhesion mediator activity	IEA Inferred from Electronic Annotation more info
enables cell-cell adhesion mediator activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adaptive immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adherens junction assembly	IEA Inferred from Electronic Annotation more info
involved_in adherens junction assembly	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in apical protein localization	IEA Inferred from Electronic Annotation more info
involved_in apical protein localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-matrix adhesion	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within cell-matrix adhesion	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of cell polarity	IDA Inferred from Direct Assay more info	PubMed
involved_in granulocyte migration	IEA Inferred from Electronic Annotation more info
involved_in granulocyte migration	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell migration to bone marrow	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic stem cell migration to bone marrow	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte migration involved in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myelination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myeloid progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of integrin activation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of integrin activation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neutrophil homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of membrane permeability	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of membrane permeability	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of monocyte extravasation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of monocyte extravasation	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell junction	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell junction	ISO Inferred from Sequence Orthology more info
involved_in protein localization to cell surface	IEA Inferred from Electronic Annotation more info
involved_in protein localization to cell surface	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of actin cytoskeleton organization by cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within spermatid development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within transmission of nerve impulse	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Schmidt-Lanterman incisure	IDA Inferred from Direct Assay more info	PubMed
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with bicellular tight junction	ISO Inferred from Sequence Orthology more info
colocalizes_with bicellular tight junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cell surface	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in cell-cell contact zone	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell contact zone	IEA Inferred from Electronic Annotation more info
located_in cell-cell contact zone	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in desmosome	ISS Inferred from Sequence or Structural Similarity more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
part_of filamentous actin	IEA Inferred from Electronic Annotation more info
part_of filamentous actin	ISO Inferred from Sequence Orthology more info
located_in microvillus	IEA Inferred from Electronic Annotation more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
located_in paranodal junction	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of protein complex involved in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
part_of protein complex involved in cell adhesion	ISO Inferred from Sequence Orthology more info
part_of protein complex involved in cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
located_in tight junction	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: junctional adhesion molecule C

Names: junction cell adhesion molecule 3; junction cell adhesion molecule C; junctional adhesion molecule 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023277.4 → NP_075766.1 junctional adhesion molecule C precursor

See identical proteins and their annotated locations for NP_075766.1

Status: VALIDATED

Source sequence(s)

AI850297, AK013156, AW106511

Consensus CDS

CCDS22939.1

UniProtKB/Swiss-Prot

Q8BT59, Q9D1M9, Q9D8B7, Q9EPK4

Related

ENSMUSP00000034472.9, ENSMUST00000034472.16

Conserved Domains (3) summary

cd00096
Location:156 → 231

Ig; Immunoglobulin domain

pfam07679
Location:39 → 135

I-set; Immunoglobulin I-set domain

cl11960
Location:37 → 118

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

27008680..27066739 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030244741.2 → XP_030100601.1 junctional adhesion molecule C isoform X1

Conserved Domains (2) summary

smart00409
Location:20 → 108

IG; Immunoglobulin

pfam13927
Location:115 → 196

Ig_3; Immunoglobulin domain
XM_036155416.1 → XP_036011309.1 junctional adhesion molecule C isoform X2

Conserved Domains (2) summary

cd00096
Location:33 → 36

Ig; Ig strand A [structural motif]

cl11960
Location:33 → 136

Ig; Immunoglobulin domain