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    Fcrla Fc receptor-like A [ Mus musculus (house mouse) ]

    Gene ID: 98752, updated on 27-Nov-2024

    Summary

    Official Symbol
    Fcrlaprovided by MGI
    Official Full Name
    Fc receptor-like Aprovided by MGI
    Primary source
    MGI:MGI:2138647
    See related
    Ensembl:ENSMUSG00000038421 AllianceGenome:MGI:2138647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FCRL; FREB; Fcrx; FCRL1; Freb1; mFREB; mFcrX; Fcrlm1
    Summary
    Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and immune response. Predicted to be located in cytoplasm. Predicted to be active in external side of plasma membrane. Is expressed in gut and male reproductive gland or organ. Orthologous to human FCRLA (Fc receptor like A). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in spleen adult (RPKM 43.6), mammary gland adult (RPKM 10.0) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Fcrla in Genome Data Viewer
    Location:
    1 H3; 1 77.65 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (170745163..170755169, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (170917594..170932216, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene dual specificity phosphatase 12 Neighboring gene STARR-seq mESC enhancer starr_02999 Neighboring gene STARR-positive B cell enhancer ABC_E7776 Neighboring gene STARR-positive B cell enhancer ABC_E5843 Neighboring gene STARR-positive B cell enhancer ABC_E11106 Neighboring gene STARR-positive B cell enhancer ABC_E4382 Neighboring gene STARR-positive B cell enhancer ABC_E4383 Neighboring gene Fc receptor-like B Neighboring gene STARR-positive B cell enhancer ABC_E3326 Neighboring gene STARR-positive B cell enhancer ABC_E5844 Neighboring gene ubiquinol-cytochrome c reductase binding protein pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E9496 Neighboring gene STARR-positive B cell enhancer ABC_E4384 Neighboring gene STARR-seq mESC enhancer starr_03000 Neighboring gene predicted gene, 39701 Neighboring gene STARR-seq mESC enhancer starr_03002 Neighboring gene Fc receptor, IgG, low affinity IIb Neighboring gene STARR-positive B cell enhancer ABC_E2584

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    Fc receptor-like A
    Names
    Fc receptor related X
    Fc receptor related protein X
    Fc receptor-like mucin-like 1
    fc receptor homolog expressed in B-cells
    fc receptor-like and mucin-like protein 1
    fc receptor-like protein
    fc receptor-related protein X

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160215.1NP_001153687.1  Fc receptor-like A isoform 1 precursor

      See identical proteins and their annotated locations for NP_001153687.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      BB219290, BC064708
      Consensus CDS
      CCDS48440.1
      UniProtKB/Swiss-Prot
      Q920A9
      Related
      ENSMUSP00000036380.8, ENSMUST00000046322.14
      Conserved Domains (3) summary
      smart00410
      Location:189262
      IG_like; Immunoglobulin like
      pfam13927
      Location:182253
      Ig_3; Immunoglobulin domain
      cl11960
      Location:90176
      Ig; Immunoglobulin domain
    2. NM_145141.2NP_660123.1  Fc receptor-like A isoform 2 precursor

      See identical proteins and their annotated locations for NP_660123.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
      Source sequence(s)
      BB219290, BB637253, BC064708
      Consensus CDS
      CCDS48439.1
      UniProtKB/Swiss-Prot
      Q3T9Q2, Q8K3U9, Q8VHP5, Q920A9
      Related
      ENSMUSP00000124853.2, ENSMUST00000159171.2
      Conserved Domains (3) summary
      smart00410
      Location:188261
      IG_like; Immunoglobulin like
      pfam13927
      Location:181252
      Ig_3; Immunoglobulin domain
      cl11960
      Location:89175
      Ig; Immunoglobulin domain

    RNA

    1. NR_027666.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. This creates an in-frame stop codon and makes this transcript a candidate for nonsense-mediated mRNA decay (NMD). Therefore, this transcript is not thought to encode a protein.
      Source sequence(s)
      BB219290, BC064708, CJ080700

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      170745163..170755169 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006497072.4XP_006497135.1  Fc receptor-like A isoform X1

      Conserved Domains (2) summary
      pfam13927
      Location:121191
      Ig_3; Immunoglobulin domain
      cl11960
      Location:28114
      Ig; Immunoglobulin domain

    RNA

    1. XR_003947561.2 RNA Sequence