IAR4 thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: IAR4
Official Full Name: thiamine diphosphate-binding fold (THDP-binding) superfamily protein
Primary source: TAIR:AT1G24180
Locus tag: AT1G24180
See related: Araport:AT1G24180
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F3I6.11; F3I6_11; IAA-CONJUGATE-RESISTANT 4
Summary: Arabidopsis thaliana pyruvate dehydrogenase E1a-like subunit. 81% identical to a previously characterized Arabidopsis mitochondrial PDH E1a-subunit, At1g59900. Serine 296 phosphorylation of IAR4 has critical function in root hair formation and root development. Changing Ser296 in IAR4 to Ala resulted in a phenotype intermediate between mutant and wild-type, while substitution to Asp was either lethal or caused an extreme dwarf phenotype.
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Genomic context

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See IAR4 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 8

Sequence:: Chromosome: 1; NC_003070.9 (8560420..8563502, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The auxin phenotypes of iar4 mutants are the result of altered indole-3-acetic acid homeostasis.
Title: Arabidopsis IAR4 modulates auxin response by regulating auxin homeostasis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102264.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cobalt ion binding	HDA more info	PubMed
enables pyruvate dehydrogenase (acetyl-transferring) activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	HDA more info	PubMed

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chloroplast	ISM Inferred from Sequence Model more info
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in nucleus	HDA more info	PubMed

General protein information

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Preferred Names: thiamine diphosphate-binding fold (THDP-binding) superfamily protein

NP_173828.1

IAA-CONJUGATE-RESISTANT 4 (IAR4); FUNCTIONS IN: cobalt ion binding, pyruvate dehydrogenase (acetyl-transferring) activity, zinc ion binding; INVOLVED IN: response to salt stress, metabolic process; LOCATED IN: cytosol, mitochondrion, nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Dehydrogenase, E1 component (InterPro:IPR001017), Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y (InterPro:IPR017597); BEST Arabidopsis thaliana protein match is: pyruvate dehydrogenase complex E1 alpha subunit (TAIR:AT1G59900.1); Has 9959 Blast hits to 9956 proteins in 1842 species: Archae - 124; Bacteria - 6117; Metazoa - 560; Fungi - 255; Plants - 209; Viruses - 0; Other Eukaryotes - 2694 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

8560420..8563502 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102264.5 → NP_173828.1 thiamine diphosphate-binding fold (THDP-binding) superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O48685, Q8H1Y0

UniProtKB/TrEMBL

A0A178WAC1, A0A5S9VTJ7

Conserved Domains (1) summary

PLN02269
Location:32 → 393

PLN02269; Pyruvate dehydrogenase E1 component subunit alpha