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    DCUN1D1 defective in cullin neddylation 1 domain containing 1 [ Homo sapiens (human) ]

    Gene ID: 54165, updated on 10-Dec-2024

    Summary

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    Official Symbol
    DCUN1D1provided by HGNC
    Official Full Name
    defective in cullin neddylation 1 domain containing 1provided by HGNC
    Primary source
    HGNC:HGNC:18184
    See related
    Ensembl:ENSG00000043093 MIM:605905; AllianceGenome:HGNC:18184
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1
    Summary
    Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DCUN1D1 in Genome Data Viewer
    Location:
    3q26.33
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (182938074..182985918, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (185743177..185791010, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (182655862..182703706, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14932 Neighboring gene ATP11B divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182516660-182517160 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:182517161-182517661 Neighboring gene Sharpr-MPRA regulatory region 857 Neighboring gene ATPase phospholipid transporting 11B (putative) Neighboring gene EIF3E pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20883 Neighboring gene C9orf85 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14935 Neighboring gene uncharacterized LOC105374246 Neighboring gene uncharacterized LOC124906309 Neighboring gene methylcrotonyl-CoA carboxylase subunit 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20884 Neighboring gene uncharacterized LOC105374247

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. The role of novel oncogenes squamous cell carcinoma-related oncogene and phosphatidylinositol 3-kinase p110alpha in squamous cell carcinoma of the oral tongue. Estilo CL, et al. Clin Cancer Res, 2003 Jun. PMID 12796399
    2. DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway. Vava A, et al. Cells, 2023 Jul 31. PMID 37566052, Free PMC Article
    3. DCUN1D1 is a risk factor for frontotemporal lobar degeneration. Villa C, et al. Eur J Neurol, 2009 Jul. PMID 19473369
    4. Squamous cell carcinoma related oncogene regulates angiogenesis through vascular endothelial growth factor-A. Talbot SG, et al. Ann Surg Oncol, 2004 May. PMID 15123463
    5. SCCRO expression correlates with invasive progression in bronchioloalveolar carcinoma. Sarkaria IS, et al. Ann Thorac Surg, 2004 Nov. PMID 15511464

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression.
      Title: Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression.
    2. DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway.
      Title: DCUN1D1 Is an Essential Regulator of Prostate Cancer Proliferation and Tumour Growth That Acts through Neddylation of Cullin 1, 3, 4A and 5 and Deregulation of Wnt/Catenin Pathway.
    3. Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
      Title: Evidence for frequent concurrent DCUN1D1, FGFR1, BCL9 gene copy number amplification in squamous cell lung cancer.
    4. DCUN1D1 activated the FAK oncogenic signaling pathway and up-regulated PD-L1.
      Title: DCUN1D1 facilitates tumor metastasis by activating FAK signaling and up-regulates PD-L1 in non-small-cell lung cancer.
    5. REVIEW: Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway
      Title: Targeting DCN1-UBC12 Protein-Protein Interaction for Regulation of Neddylation Pathway.
    6. Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA
      Title: Expression of DCUN1D1 in laryngeal squamous cell carcinoma and its inhibiting effect on TU-177 cells after interfered by RNA.
    7. ubiquitin-associated (UBA) domain-containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain.
      Title: Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.
    8. The expression of DCUN1D1 was significantly increased in colorectal cancer with a negative correlation to miR-520b expression in colorectal cancer tissues.
      Title: MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1).
    9. the DCN1-UBC12 interaction is inhibited by DI-591, a high-affinity, cell-permeable small-molecule inhibitor that binds to purified recombinant human DCN1 and DCN2 proteins with K i values of 10-12 nM
      Title: A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks cullin 3 neddylation.
    10. SCRO has potential to become a new target for the treatment of PC
      Title: Clinical significance of SCCRO (DCUN1D1) in prostate cancer and its proliferation-inhibiting effect on Lncap cells.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein neddylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein neddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of protein ubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DCN1-like protein 1
    Names
    DCN1, defective in cullin neddylation 1, domain containing 1
    DCUN1 domain-containing protein 1
    RP42 homolog
    defective in cullin neddylation protein 1-like protein 1
    squamous cell carcinoma-related oncogene

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308101.2 → NP_001295030.1  DCN1-like protein 1 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate 5' exon, contains an alternate 5' terminal exon, and uses a downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC092953, AF292100, AK025764, AW103206, BC013163, BI828039, BU620603, HY052047
      Consensus CDS
      CCDS77862.1
      UniProtKB/TrEMBL
      B4DM76, C9JUW4, C9JVE2
      Related
      ENSP00000419359.1, ENST00000469954.5
      Conserved Domains (2) summary
      pfam03556
      Location:121 → 231
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 36
      UBA_like_SF; UBA domain-like superfamily

    2. NM_020640.4 → NP_065691.2  DCN1-like protein 1 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC092953, AF292100, AK025764, AK297328, AW103206, BC013163, BU620603
      Consensus CDS
      CCDS3240.1
      UniProtKB/Swiss-Prot
      B2RB37, Q7L3G9, Q8TEX7, Q96GG9, Q9H6M1, Q9HCT3
      UniProtKB/TrEMBL
      B4DM76
      Related
      ENSP00000292782.4, ENST00000292782.9
      Conserved Domains (2) summary
      pfam03556
      Location:136 → 246
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 51
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      182938074..182985918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453601.2 → XP_024309369.2  DCN1-like protein 1 isoform X4

    2. XM_047448339.1 → XP_047304295.1  DCN1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      B4DM76

    3. XM_011512914.2 → XP_011511216.1  DCN1-like protein 1 isoform X3

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 219
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 36
      UBA_like_SF; UBA domain-like superfamily

    4. XM_011512915.3 → XP_011511217.1  DCN1-like protein 1 isoform X3

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 219
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 36
      UBA_like_SF; UBA domain-like superfamily

    5. XM_011512916.3 → XP_011511218.1  DCN1-like protein 1 isoform X3

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 219
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 36
      UBA_like_SF; UBA domain-like superfamily

    6. XM_047448340.1 → XP_047304296.1  DCN1-like protein 1 isoform X3

    7. XM_047448338.1 → XP_047304294.1  DCN1-like protein 1 isoform X1

    8. XM_011512912.3 → XP_011511214.1  DCN1-like protein 1 isoform X1

      Conserved Domains (2) summary
      pfam03556
      Location:136 → 234
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 51
      UBA_like_SF; UBA domain-like superfamily

    9. XM_017006634.1 → XP_016862123.1  DCN1-like protein 1 isoform X3

      Conserved Domains (2) summary
      pfam03556
      Location:121 → 219
      Cullin_binding; Cullin binding
      cl21463
      Location:1 → 36
      UBA_like_SF; UBA domain-like superfamily

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      185743177..185791010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346910.1 → XP_054202885.1  DCN1-like protein 1 isoform X5

      UniProtKB/TrEMBL
      B4DM76, C9JUW4, C9JVE2

    2. XM_054346906.1 → XP_054202881.1  DCN1-like protein 1 isoform X2

      UniProtKB/TrEMBL
      B4DM76

    3. XM_054346907.1 → XP_054202882.1  DCN1-like protein 1 isoform X3

    4. XM_054346909.1 → XP_054202884.1  DCN1-like protein 1 isoform X3

    5. XM_054346905.1 → XP_054202880.1  DCN1-like protein 1 isoform X1

    6. XM_054346904.1 → XP_054202879.1  DCN1-like protein 1 isoform X1

    7. XM_054346908.1 → XP_054202883.1  DCN1-like protein 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96GG9.1 GenPept UniProtKB/Swiss-Prot:Q96GG9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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