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    ZSCAN18 zinc finger and SCAN domain containing 18 [ Homo sapiens (human) ]

    Gene ID: 65982, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ZSCAN18provided by HGNC
    Official Full Name
    zinc finger and SCAN domain containing 18provided by HGNC
    Primary source
    HGNC:HGNC:21037
    See related
    Ensembl:ENSG00000121413 AllianceGenome:HGNC:21037
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF447
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 14.7), endometrium (RPKM 11.3) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZSCAN18 in Genome Data Viewer
    Location:
    19q13.43
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (58083842..58118426, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (61180644..61214896, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58595209..58629793, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 135 Neighboring gene RNA, 7SL, cytoplasmic 526, pseudogene Neighboring gene zinc finger protein 329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15178 Neighboring gene uncharacterized LOC124904784

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer. Wang Y, et al. Front Endocrinol (Lausanne), 2023. PMID 37223020, Free PMC Article
    2. Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells. Li B, et al. Clin Epigenetics, 2023 Jan 17. PMID 36650573, Free PMC Article
    3. Development of a highly specific HER2 monoclonal antibody for immunohistochemistry using protein microarray chips. Qi L, et al. Biochem Biophys Res Commun, 2017 Mar 4. PMID 28111342
    4. The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers. Vedeld HM, et al. Int J Cancer, 2015 Feb 15. PMID 24948044, Free PMC Article
    5. The in vivo Interaction Landscape of Histones H3.1 and H3.3. Siddaway R, et al. Mol Cell Proteomics, 2022 Oct. PMID 36089195, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer.
      Title: Zinc finger and SCAN domain-containing protein 18 is a potential DNA methylation-modified tumor suppressor and biomarker in breast cancer.
    2. Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells.
      Title: Inactivation of ZSCAN18 by promoter hypermethylation drives the proliferation via attenuating TP53INP2-mediated autophagy in gastric cancer cells.
    3. A high negative correlation between promoter DNA methylation and gene expression was observed for CDO1, ZNF331 and ZSCAN18 in gastrointestinal tumors.
      Title: The novel colorectal cancer biomarkers CDO1, ZSCAN18 and ZNF331 are frequently methylated across gastrointestinal cancers.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2427, MGC4074, MGC8682, FLJ12895, FLJ38919, FLJ44152, DKFZp586B1122

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and SCAN domain-containing protein 18
    Names
    zinc finger protein 447

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145542.1 → NP_001139014.1  zinc finger and SCAN domain-containing protein 18 isoform 1

      See identical proteins and their annotated locations for NP_001139014.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest protein (isoform 1).
      Source sequence(s)
      AK294376, BC006205, DC354023
      Consensus CDS
      CCDS46214.1
      UniProtKB/Swiss-Prot
      Q8TBC5
      Related
      ENSP00000470123.1, ENST00000600404.1
      Conserved Domains (3) summary
      smart00349
      Location:284 → 321
      KRAB; krueppel associated box
      sd00017
      Location:471 → 491
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:102 → 189
      SCAN; SCAN domain

    2. NM_001145543.2 → NP_001139015.1  zinc finger and SCAN domain-containing protein 18 isoform 3

      See identical proteins and their annotated locations for NP_001139015.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same protein (isoform 3), which is shorter when it is compared to isoform 1.
      Source sequence(s)
      AY280799, BC006205
      Consensus CDS
      CCDS12971.1
      UniProtKB/Swiss-Prot
      B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
      Related
      ENSP00000468934.1, ENST00000601144.6
      Conserved Domains (3) summary
      smart00349
      Location:228 → 265
      KRAB; krueppel associated box
      sd00017
      Location:415 → 435
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain

    3. NM_001145544.2 → NP_001139016.1  zinc finger and SCAN domain-containing protein 18 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. The resulting protein (isoform 2) has a shorter N-terminus when it is compared to isoform 1.
      Source sequence(s)
      BC006205, BG036776, DA611622
      Consensus CDS
      CCDS46215.1
      UniProtKB/TrEMBL
      A0A0C4DG78
      Related
      ENSP00000392653.1, ENST00000421612.6
      Conserved Domains (2) summary
      smart00349
      Location:93 → 130
      KRAB; krueppel associated box
      sd00017
      Location:279 → 299
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. NM_023926.5 → NP_076415.3  zinc finger and SCAN domain-containing protein 18 isoform 3

      See identical proteins and their annotated locations for NP_076415.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses a different segment for its 5' UTR and lacks a coding region segment, which results in the use of a downstream start codon, compared to variant 1. Variants 3 and 4 encode the same protein (isoform 3), which is shorter when it is compared to isoform 1.
      Source sequence(s)
      BC006205, BC022846, BG036776
      Consensus CDS
      CCDS12971.1
      UniProtKB/Swiss-Prot
      B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
      Related
      ENSP00000240727.5, ENST00000240727.10
      Conserved Domains (3) summary
      smart00349
      Location:228 → 265
      KRAB; krueppel associated box
      sd00017
      Location:415 → 435
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain

    RNA

    1. NR_027135.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) represents transcription from an upstream promoter and shares the first exon with variant 1. This two-exon transcript includes a different terminal exon but the predicted protein is not represented because there is uncertainty about the protein-coding capacity of the transcript.
      Source sequence(s)
      AC008751
      Related
      ENST00000595944.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      58083842..58118426 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011527239.4 → XP_011525541.1  zinc finger and SCAN domain-containing protein 18 isoform X2

      See identical proteins and their annotated locations for XP_011525541.1

      UniProtKB/Swiss-Prot
      B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
      Conserved Domains (3) summary
      smart00349
      Location:228 → 265
      KRAB; krueppel associated box
      sd00017
      Location:415 → 435
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain

    2. XM_006723335.3 → XP_006723398.1  zinc finger and SCAN domain-containing protein 18 isoform X2

      See identical proteins and their annotated locations for XP_006723398.1

      UniProtKB/Swiss-Prot
      B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
      Conserved Domains (3) summary
      smart00349
      Location:228 → 265
      KRAB; krueppel associated box
      sd00017
      Location:415 → 435
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain

    3. XM_011527238.2 → XP_011525540.1  zinc finger and SCAN domain-containing protein 18 isoform X2

      See identical proteins and their annotated locations for XP_011525540.1

      UniProtKB/Swiss-Prot
      B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
      Conserved Domains (3) summary
      smart00349
      Location:228 → 265
      KRAB; krueppel associated box
      sd00017
      Location:415 → 435
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain

    4. XM_005259174.6 → XP_005259231.1  zinc finger and SCAN domain-containing protein 18 isoform X2

      See identical proteins and their annotated locations for XP_005259231.1

      UniProtKB/Swiss-Prot
      B4DG23, E9PBI0, Q8TBC5, Q9BRK7, Q9H9A0
      Conserved Domains (3) summary
      smart00349
      Location:228 → 265
      KRAB; krueppel associated box
      sd00017
      Location:415 → 435
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:46 → 133
      SCAN; SCAN domain

    5. XM_011527237.3 → XP_011525539.1  zinc finger and SCAN domain-containing protein 18 isoform X1

      Conserved Domains (3) summary
      smart00349
      Location:284 → 321
      KRAB; krueppel associated box
      sd00017
      Location:470 → 490
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam02023
      Location:102 → 189
      SCAN; SCAN domain

    6. XM_017027169.3 → XP_016882658.1  zinc finger and SCAN domain-containing protein 18 isoform X3

      UniProtKB/Swiss-Prot
      Q8TBC5
      Related
      ENSP00000412253.2, ENST00000433686.6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      61180644..61214896 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321830.1 → XP_054177805.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    2. XM_054321828.1 → XP_054177803.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    3. XM_054321829.1 → XP_054177804.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    4. XM_054321831.1 → XP_054177806.1  zinc finger and SCAN domain-containing protein 18 isoform X2

    5. XM_054321827.1 → XP_054177802.1  zinc finger and SCAN domain-containing protein 18 isoform X1

    6. XM_054321832.1 → XP_054177807.1  zinc finger and SCAN domain-containing protein 18 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8TBC5.2 GenPept UniProtKB/Swiss-Prot:Q8TBC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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